University of Khartoum

Comparative Effects of Injectable and Oral Hormonal Contraceptives on Blood lipid Profile in Women in Nile Valley State Sudan

Comparative Effects of Injectable and Oral Hormonal Contraceptives on Blood lipid Profile in Women in Nile Valley State Sudan

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Title: Comparative Effects of Injectable and Oral Hormonal Contraceptives on Blood lipid Profile in Women in Nile Valley State Sudan
Author: Mohamed, Fatima Abdel GabirElamin
Abstract: Hormonal contraceptives (HCs) were known to cause controversial alterations in the blood lipid profile, with different patterns of dyslipidemia and cardiovascular risk. In Sudan the use of HCs is very common, but very little data is available about their effects on blood lipid profile. Also the different preparationsof HCswere not comparedto evaluate the risk of their use. This is a retrospective study conducted to compare the effects of, injectable (InjCs) and oral contraceptives (OrCs) on lipid profile in Sudanese women. Fasting blood samples were collected from 60 women within reproductive age visited El mekNimer Teaching Hospital in Shendi, for routine checkup. Twenty of them were using oral contraceptive (Desogestrel 0.15mg /ethinyl estradiol (EE) 0.03mg) and other 20 were using injectable contraceptive Depot medroxyprogesterone acetate (DMPA) for more than two years , both categories were compared to 20 ladies,who never used birth control methods, and used as control group. Lipid profile was determined, in all groups, using enzymatic colorimetric methods. One way ANOVA was used to compare between groupsand the statistical analysis of the data revealed significant differences. Women using OrCs showed values for the Total cholesterol (TC)of 142.4±5.53mg/dl, the HDL-C 43.13±1.50 mg/dl, and the triglycerides (TG) 114.21±0.65mg/dl which were significantly higher (p<0.05) compared to the control group. Whereas the group used InjCs showed significantly (P<0.05) lower levels of the LDL-C 77.41.±0.85 mg/dl and higher HDL-C 48.2±0.80 mg/dl compared to the control group. When the two test groups were compared, the group used OrCs showed significantly (P<0.05) elevated levels of triglycerides 114.21±0.65, LDL-C 81.30±0.85 mg/dl and Total cholesterol 142.4±5.53 mg/dl with significantly (P<0.05) lower, HDL-C 43. 20±0.80 mg/dl levels compared with the InjCs users. When the age factor was compared , the LDL-C showed significantly (P<0.05) lower value 77.21±0.80mg/dl in elder ladies using InjCs, of age between 37-48 years old compared to the younger ones, of age range between 25-36 years. Also the HDL-C showed significantly (P<0.05) lower levels 38.20± 0.64 mg/dl and 36.23±2.30 mg/dl in elder ladies used InjCs or OrCs respectively compared to their respective younger groups. Using hormonal contraceptives resulted in clear changes in the blood lipid profile of Sudanese women. OrCs increased the LDL-C, TC and TG compared to their levels in the injected group. Moreover, women injected with HCs showed significantly lower LDL-C in elderly injected ladies than younger ones. In conclusion changes of lipid profile in this study suggested that using oral contraceptives can augment cardiovascular risk. On the other hand the use of injectable preparations might be of beneficial effects to blood lipids profile but elderly women, using InjCs, should be monitored as they reported low HDL-C. Although the changes, seen here, were within the normal levels of theblood lipid profile, but women with existing dyslipidemia, resulted from any stressing disease, might be in danger.
Description: 59 Pages
URI: http://khartoumspace.uofk.edu/123456789/24485


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