University of Khartoum

Cytomorphological Patterns of Cervical Smears of Sudanese Infertile Women in Khartoum State (January 2014 through December 2015)

Cytomorphological Patterns of Cervical Smears of Sudanese Infertile Women in Khartoum State (January 2014 through December 2015)

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Title: Cytomorphological Patterns of Cervical Smears of Sudanese Infertile Women in Khartoum State (January 2014 through December 2015)
Author: Alsidig, Enas Jaffer Yousif
Abstract: Background: Several studies suggested thatwomen with infertility are at high-risk of developing cervical intraepithelial lesions or even carcinoma. Design: This is an observational, analytical, case control study. Setting: The study was conducted in Saad Abu Elaa Hospital; Omdurman Maternity Hospital; and Ashmieqe Center- Khartoum Sate, Sudan. Objectives: The aim of this study was to identify the cytomorpholgical changes of cervical smears collected from infertile and fertile Sudanese females using PAP technique. Methods: Cervical smears were collected using speculum to open the vagina and spatula to sweep around the cervix.The samples of the cells and all cytological scrapped materials were prepared directly on the slides and immediately fixed, dehydrated (ethanol 95%), then were smeared, stained with Pap stain and examined under light microscope Olympus CX 41(Japan)and the results were reported using the revised Bethesda System. Other variables were collected through a questionnaire following informed consent.Results were analyzed using SPSS and P.value 0.05 was considered statistically significant. Results:Out of 330 cervical smears (165 from infertile and 165 from fertile women with age ranging from 15 to 45 years old),22(13.33%) of the infertile and 16 (9.69%) of the fertile women showed abnormal epithelial changes.This study also revealed that9, 7, 3, 2 and 1 out of the 22 cases with epithelial cell abnormalities were found to be low grade squamous intraepithelial lesions,high grade squamous intraepithelial lesions (HSIL), atypical squamous cell of undetermined significance, atypical glandular cells, and squamous cell carcinoma, respectively, while in the control group these tapes were 9, 1, 2, 3 and 1, respectively. The cervical smears stained by PAP stain from the infertile and fertile women showedsignificantly different results (P = 0.013 < 0.05). Conclusion: Cervical smears from infertile women aresignificantly associated with cytomorphlogical changes particularly of HSIL. The study recommends screening of infertile women and integration of cervical cancer screening programme in primary health care services.
Description: 88 Pages
URI: http://khartoumspace.uofk.edu/123456789/24621


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