University of Khartoum

Synthesis and Pharmacological Effect of Substituted Phenyl-4-(2-Chloroethyl) Tetrahydro-1, 4-Oxazine Hydrochlorides

Synthesis and Pharmacological Effect of Substituted Phenyl-4-(2-Chloroethyl) Tetrahydro-1, 4-Oxazine Hydrochlorides

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Title: Synthesis and Pharmacological Effect of Substituted Phenyl-4-(2-Chloroethyl) Tetrahydro-1, 4-Oxazine Hydrochlorides
Author: Daoud, SS; Osman, SA; Karrar, MA
Abstract: Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed.
URI: http://khartoumspace.uofk.edu/123456789/24787


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