University of Khartoum

Stability Studies on Florfenicol Using Developed Derivative Spectrophotometric Methods

Stability Studies on Florfenicol Using Developed Derivative Spectrophotometric Methods

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Title: Stability Studies on Florfenicol Using Developed Derivative Spectrophotometric Methods
Author: Elimama, M M.; Shantier, S W.; Gadkariem, E A.; Mohamed, Magdi A.; Osman, Z.
Abstract: Objectives. — This study aims to investigate the stability of florfenicol using previously developed derivative spectrophotometric methods (D1 and D2). Methods. — The studied stability-indicating pararmeters included alkali (NaOH, 1 M), acid (HCl, 1 M), pH changes (buffer pH 2.2—11), temperature (80 ◦C and 100 ◦C at pH 10) and light. Result. — A constructed pH profile for the drug degradation rate revealed a significant effect of pH on the drug stability between pH ranges 8 and 11. The obtained profile indicated first order dependence of Kobs on [OH−]. Arrhenius plot at pH 10 was found linear at temperatures 80 ◦C and 100 ◦C with estimated activation energy of 19.35 kcal/mol. The calculated rate constant (Kobs), t½ and t90 at 25 ◦C were found to be 1.8 × 10−3 h, 385 h and 58.3 h, respectively. The photostability of florfenicol was also studied by exposing the drug solution to direct sunlight during mid-day time. Conclusion. — The obtained results reflected the instability of florfenicol under the study conditions.
URI: http://khartoumspace.uofk.edu/123456789/25099


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