University of Khartoum

Spectrophotometric Determination of Tranexamic Acid in Bulk and Dosage Forms Using Ascorbic Acid

Spectrophotometric Determination of Tranexamic Acid in Bulk and Dosage Forms Using Ascorbic Acid

Show full item record

Title: Spectrophotometric Determination of Tranexamic Acid in Bulk and Dosage Forms Using Ascorbic Acid
Author: Mohamed, Magdi A.; Gadkariem, Elrasheed A.; Jabbir, Maha A A.
Abstract: A simple spectrophotometric method for the determination of tranexamic acid (TA) in pure form and pharmaceutical preparations was developed. The method is based on coupling tranexamic acid with ascorbic acid (AA) in dimethyl sulfoxide (DMSO) to produce a colored product which absorbs maximally at two wavelengths (λmax) 390nm & 530nm. The molar ratio of tranexamic acid: ascorbic acid is 1:2. Beer’s law is obeyed in the concentration range 10-25µg/ml of tranexamic acid with molar absorbtivity of 2.4×103 L mol-1cm-1(λmax390nm) and 0.73×103 L mol-1cm-1 (λmax530nm). Different experimental parameters affecting the development and stability of the color were studied and optimized. The proposed method was validated against an adopted B.P formal titration method. The mean percentage recovery obtained for the assay of commercial capsules was found to be 99.77±1.02 (λmax390nm) and 101.01±0.97 (λmax530nm).
URI: http://khartoumspace.uofk.edu/123456789/25123


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account