University of Khartoum

Assessment the Effect of Omega-3 Fatty Acid Supplementation in Sudanese patients with Sickle Cell Anemia; Khartoum, Sudan

Assessment the Effect of Omega-3 Fatty Acid Supplementation in Sudanese patients with Sickle Cell Anemia; Khartoum, Sudan

Show simple item record

dc.contributor.author Mohammed, Babiker A.
dc.contributor.author Elzubeir, Alaaeddin Musaad. M.
dc.contributor.author Elmahdi, Tariq.E.Elmisbah
dc.contributor.author Addak, Ahmed A.
dc.contributor.author Abdelfarag, Magdi Mansoor
dc.date 2017
dc.date.accessioned 2017-08-13T10:37:29Z
dc.date.available 2017-08-13T10:37:29Z
dc.date.submitted 2014
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/25387
dc.description.abstract Background: Sickle cell disease (SCD) is a group of genetic blood disorders characterized by a single point mutation in the sixth codon of the β-globin gene. Under low oxygen tension, the resultant abnormal hemoglobin S polymerizes and causes rigid and sickle-shaped red blood cells. Objectives: This study aimed to assess the effect of omega-3 supplementation in patients with sickle cell anemia. Subjects and methods: Seventy-eight SCD patients, who were undergoing regular follow-up at the outpatients SCD clinic in Ibn-Aoaf Pediatrics and Khartoum hospitals, were the main study group and 35 individuals were selected as control group. Patients recruited randomly were assigned to receive omega-3 fatty acid supplementation for at least two years. 5 ml of venous blood was collected from every individual into EDTA test tubes and used to determine complete blood count (CBC), electrophoresis and reticulocyte count. Results: A significant difference in the Hb (g/dl) mean between the omega-3 group and the group free of omega-3 (P. value < 0.0001) was recorded. Also in total red blood cells count X 103C/M l, hematocrit and mean cell hemoglobin pg (P.value < 0.05) .No difference in levels between the study groups at mean cell volume / f l and mean cell hemoglobin concentration % (P. value < 0.05). Retics count and reticulocyte production index significant decrease in omega-3 group compared to control group (P.value < 0.0001). Conclusions: These findings suggest that omega-3 fatty acids can be an effective, safe, and affordable therapy for sickle cell anemia. en_US
dc.publisher university of khartoum en_US
dc.subject Sickle cell anemia, Omega-3 Fatty Acid, , Khartoum, Sudan. en_US
dc.title Assessment the Effect of Omega-3 Fatty Acid Supplementation in Sudanese patients with Sickle Cell Anemia; Khartoum, Sudan en_US
dc.type Publication en_US
dc.Faculty Medicine en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account