University of Khartoum

Comparative Pharmacokinetic Profile of Two Tetramisole Products after Oral Administration in Goats

Comparative Pharmacokinetic Profile of Two Tetramisole Products after Oral Administration in Goats

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Title: Comparative Pharmacokinetic Profile of Two Tetramisole Products after Oral Administration in Goats
Author: Adam, Marwa Ismail Mohammed Elhussien
Abstract: This study was designed to compare the pharmacokinetic profile of two different tetramisole products after oral administration in goat Eight apparently healthy male goats aged 2-3 years and weighed 24 -28 kg were used , divided into two equal groups of 4 animals each. Group 1 received drug A (Tetramisole Hydrochloride 10%, Pamizole PS ® Bash Pharma CO. LTD Sudan) at dose rate of 0.1 mg/kg BW orally and group 2 received drug B (Tetramisole Hydrochloride 10%, Pamizole PS ®Fatros.p.a Italy) at dose rate of 0.1 mg/kg BW orally. Plasma samples were collected at 0, 5, 20, 30, 40, 60, 75, 90, 120, 150, 180, 240, 300 and 360 min after drug administration. Plasma tetramisole concentration was determined by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection at wave length 225 nm .The drug plasma concentration vs time curve for each individual animal was fitted with a drug kinetic computer program. Pharmacokinetic parameters including Maximum concentration in plasma , Area under concentration time curve from zero to Time, Area under concentration time curve from Zero up to ∞ , Time to achieve maximum concentration , Elimination half-life , Clearance , Mean residence time and Volume of distribution at steady state for each animal were analyzed using non- compartmental model analysis with extra vascular input for tetramisole. Results showed that the value of AUC0-t was significantly (P< 0.05) larger for drug A which was 4271.8±44.04µg.min/ml versus 3093.9±399.7µg .min/ml for drug B, while there was no significant difference (P> 0.05) in the value of AUC0-∞ between drug A which was 3931.4±28.5 µg .min/ml versus 2615.8±57.4µg.min/ml for drug B. There was significant difference (P< 0.05) in the value of Cmax between drug A which was 21.1± 0.15 µg /ml versus 20.3±0.34 µg/ml for drug B. Drug A took longer time to reach maximum concentration in the plasma (Tmax ) which was 90±0.000 min versus75±0.000 min for drug B. Longer half-life (T1/2: 136±74.8min versus 80± 2.6 min) and mean residence time (MRT: 202±67.2min versus176 ±2.35 min) were observed in drug B compared with drug A. There was significant difference (P<0.05) in drug clearance (0.023± 0.000 ml/kg. min for drug A versus 0.032±0.003 ml/kg. min for drug B). There was no significant difference (P>o.05) in the mean values of Vss (4±0.05 L/Kg for drug A versus 6.3±1.22 L/Kg for drug B). The study concluded that the locally manufactured tetramisole has a good pharmacokinetic disposition when compared with the standard product manufactured in Italy which can reflect its effectiveness as anthelmintic drug. It is recommended to conduct similar studies in other animal species and to evaluate its efficacy against different parasitic helminthes.
URI: http://khartoumspace.uofk.edu/123456789/25834


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