University of Khartoum

The Hypolipidaemic Effect of The Ethanolic Extract of Hibiscus sabdariffa L. Calyces on Induced Hyperlipidaemia in Albino Rats

The Hypolipidaemic Effect of The Ethanolic Extract of Hibiscus sabdariffa L. Calyces on Induced Hyperlipidaemia in Albino Rats

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Title: The Hypolipidaemic Effect of The Ethanolic Extract of Hibiscus sabdariffa L. Calyces on Induced Hyperlipidaemia in Albino Rats
Author: Mohammed, Egbal Yousif Gaffer
Abstract: This study was conducted to evaluate the effect of ethanolic extract of the calyces of roselle (Hibiscus sabdariffa L.) on serum levels of lipid profile (cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL)) in hyperlipidaemic albino rats. The ethanolic extract of Hibiscus sabdariffia calyces was prepared by soaking the dried calyces of the plant in 80% ethanol for three days and then filtered and the filtrate was dried. 32 rats were divided randomly into four groups, of 8 rats each. All groups (An, Ap, B and C) were fed a standard normal diet for one week, then groups Ap, B and C were fed a hyperlipidaemic formula (2g/10ml),orally for one week (9.6g of cholesterol powder dissolved in 50 ml of ghee(milk lipids)) . Groups B and C were administered 1000 mg/kg and 500 mg/kg of Hibiscus sabdariffa extract, respectively for four weeks .Groups An and Ap were kept as negative and positive controls, respectively. Blood samples were collected from all rats on days 0, 7,14,21,28 and 35 for determination of lipids profile. The findings of this study revealed a significant (P ≤ 0.05) hypolipidaemic effect produced by dose 500 mg/kg at day 35 which reduced serum cholesterol, triglycerides, LDL and increased serum HDL significantly (P ≤ 0.05). It was concluded that Hibiscus sabdariffa L. has a potent lipid lowering activity and this confirms its traditional use as a lipid lowering therapeutic agent.
URI: http://khartoumspace.uofk.edu/123456789/25841


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