University of Khartoum

Evaluation of Oral Exfoliative Cytology (OEC) for Screening and Early Diagnosis of Squamous Cells Carcinoma (SCC)

Evaluation of Oral Exfoliative Cytology (OEC) for Screening and Early Diagnosis of Squamous Cells Carcinoma (SCC)

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Title: Evaluation of Oral Exfoliative Cytology (OEC) for Screening and Early Diagnosis of Squamous Cells Carcinoma (SCC)
Author: Bushara, Maha Hamid Omer
Abstract: Background: In Sudan, oral cancer considered as the second most common cancer with a high incidence which considered as the second highest incidence of oral cancer in Africa. Although, oral exfoliative cytology (OEC) is a reliable method for screening and early detection of OSCC, in Sudan, there are few reported studies assessing the diagnostic value of OEC in comparison to histopathology. The objective of this study was to compare the cytological results with histopathological results, and to analyze the sensitivity and specificity of oral exfoliative cytology in detecting OSCC. Methods: Smears for cytological examination and biopsies for histopathological diagnosis were taken from each of the study cases that were clinically diagnosed with OSCC. Results: From the total 45 study cases, histopathology showed the presence of OSCC in 39(86.7%) cases, hyperkeratosis in 4(8.9%) cases and verrucous carcinoma in 2(4.4%) cases. The male to female ratio in OSCC was 3.8:1 (P value = 0.000), and the majority of OSCC cases were older than 50 years. Most of OSCC cases, 82.1% (n=32), were Toombak dippers and the majority were males, 87.5% (n=28). In addition, labiogingiva, a common site of Toombak dipping, was a prevalent lesion site of OSCC 33.3% (n=13), (P value = 0.004). Histopathological diagnosis confirmed cytological diagnosis of OSCC in 31 out of 39 cases (79.5%) and confirmed the cytological diagnosis in all 6 non OSCC cases. Conclusion: Oral exfoliative cytology technique is a rapid, efficient, cost effective, relatively painless and useful diagnostic procedure.
Description: 109 page
URI: http://khartoumspace.uofk.edu/123456789/25931


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