University of Khartoum

Thyroid Function Test in Patients with Chronic Kidney Disease

Thyroid Function Test in Patients with Chronic Kidney Disease

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Title: Thyroid Function Test in Patients with Chronic Kidney Disease
Author: Eljack, Khansa A.Rahman
Abstract: Background: Thyroid disorders in chronic renal failure are common and have a lot of morbidity and mortality. Accurate diagnosis of these disorders needs measurement of thyroid function test (T3,T4andTSH) in patients of chronic kidney disease, treatment of patients by haemodialysis is also accompanied by thyroid hormones changes. There have been no documented efforts in Sudan to detect these disorders .this study meant for detection of thyroid hormones level in patients with chronic kidney disease both haemodialized and non haemodialized. The study also investigated the correlation between the thyroid hormones level and age, gender and duration of the disease and hemodialysis in those patients. Methods: This is a prospective study carried out at Omdurman military hospital. Data was collected from 60 patients of CKD, they were further divided into two groups ,30 non dialyzed and 30 on regular hemodialysis. T3 and T4and TSH were measured using competitive enzyme immunoassay. Result: In 60 patients of chronic kidney disease are studied. their thyroid function tests (T3,T4andTSH) were low in 39 cases(60%),17 cases(28.3%) and 4cases(6.6%) respectively. In the non-dialyzed group (30patients) T3 was found to be low in 46.7%.. There was no significant relationship between age, sex and duration of the disease and thyroid hormone level in this group (P value=0.34),(P value=0.86) ,( P value=97) respectively. IV In haemodialized patients( T3,T4and TSH) were low in (63.3%),(56.6%) and (6.7%) respectively of the studied group . The gender, age and duration of hemodialysis of the studied group did not affect their thyroid hormone level (P value=0.287),(P value=0. 22)and(P value=0.287). .Conclusion: In this study uremia affect thyroid hormone level in HD and non HD patients. The most common change is low T3.there is no relation between the age, gender and duration of the disease and haemodialysis. Evaluation of thyroid dysfunction is important as it may affect the patient management.
URI: http://khartoumspace.uofk.edu/123456789/25969


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