University of Khartoum

Histopathological Grading and Staging of Chronic Hepatitis at Soba University Hospital

Histopathological Grading and Staging of Chronic Hepatitis at Soba University Hospital

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Title: Histopathological Grading and Staging of Chronic Hepatitis at Soba University Hospital
Author: Eltayeb, Huda Hussein Elwasila
Abstract: Background: Chronic hepatitis is the common cause of morbidity worldwide. Sudan is classified among countries with a high hepatitis B surface antigen (HBsAg) endemicity of more than 8%. However, hepatitis C virus in Sudan demonstrated a low seroprevalence ranging from 2.2% to 4.8%. Histological scoring systems for chronic liver disease are used to characterize and predict disease progression, to determine prognosis, to guide treatment strategies, and to provide standards in clinical trials. This study was done to give a clue about the grading and staging of chronic hepatitis in Sudan. Materials and Methods: The present study was cross-sectional hospital-based study, it included 57 patients. Sections from formalin fixed paraffin embedded tissue blocks of chronic hepatitis specimens seen at Department of Histopathology in Soba University Hospital in the period from January 2004 to December 2015 were examind. Demographic and clinical relevant data were collected from patient's records. The slides were reviewed by the candidate and the supervisor. Grading and staging were reclassified histologically according to Modified Histological Activity Index classification (Ishak), which is not commonly used. Data were analyzed using SPSS. Results: Out of 57 patients, 35 (61.4%) were males. Most of the patients (26.3%) were between 51-60 years of age; and 7% were less than 10 years old. Patients with mild chronic hepatitis grade 2 represent more than half of cases (56.1%), while minimal chronic hepatitis grade 1 and moderate chronic hepatitis grade 3 represented 9 (15.8%) cases of each, followed by 7 cases of severe chronic hepatitis grade 4 (12%). Stage 1 represented the highest percentage of cases (36.8%). Stage 3 and 5 were (15.8%) for each, while Stage 4, 2 and 0 were (14%), (12.3%), and (5.3%) respectively. Twelve cases were diagnosed as hepatitis B (21.1%), three cases were hepatitis C (5.3%), only one case was diagnosed as autoimmune hepatitis (1.8%). Most records have incomplete clinical information (59.7%) and seven cases (12.3%) had no clinical remarks at all. Conclusion: The majority of chronic hepatitis patients were elderly patients which carried a bad prognosis with predominance of males. Most patients included in this study were in early stages of the disease. More than half were grade 2 and most patients were stage 1. Hepatitis B is the leading cause of chronic hepatitis in Sudan.
URI: http://khartoumspace.uofk.edu/123456789/25973


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