University of Khartoum

The Relationship of E2/T Ratio as an Indicator of the Aromatase Activity with Levels of Estradiol, Testosterone and Bmi in Sudanese Women with Polycystic Ovary Syndrome

The Relationship of E2/T Ratio as an Indicator of the Aromatase Activity with Levels of Estradiol, Testosterone and Bmi in Sudanese Women with Polycystic Ovary Syndrome

Show simple item record

dc.contributor.author Khandgawi, Mustafa Abdelgadir
dc.contributor.author Morsi, Adel Nasr
dc.contributor.author Mohamed, Liza Hamdi
dc.contributor.other Chemical Pathology en_US
dc.date 2016
dc.date.accessioned 2018-01-21T08:21:19Z
dc.date.available 2018-01-21T08:21:19Z
dc.date.submitted 2018
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/26050
dc.description.abstract Background: Determination of E2/T ratio provides necessary data regarded to aromatase activity which significantly plays a vital role and directly associated with the generation and metabolism of sex hormone for girls of reproductive age. Our aim was to explain the relationship between aromatase activity with levels of Estradiol (E2), Testosterone (T) levels and Body mass index (BMI) in Sudanese women with PCOS or without PCOS. Methodology: A total of 40 PCOS cases diagnosed according to Rotterdam criteria 2003 and 40 ovulatory normal – non PCOs, healthy, age-matched women as control. Serum Estradiol (E2) and Testosterone (T) on the third day of the menstrual cycle were measured using manual ELISA technique. Both E2/T ratio and Body Mass Index (BMI) were calculated. The Data management and analysis were done by SPSS version 22. Results: E2/T ratio, E2 were highly significantly lower (P < 0.01) while T levels was highly significantly higher (P < 0.01) in PCOS patients. However, no significant difference was observed in BMI of either PCOS or control. Conclusion: Our study suggests that higher testosterone levels in the ovary shut down the activity of the aromatase enzyme and improving aromatase activity may become an optimized approach for remedy options for PCOS women. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject PCOS, Armatase enzyme, Estradiol, Testosterone. en_US
dc.title The Relationship of E2/T Ratio as an Indicator of the Aromatase Activity with Levels of Estradiol, Testosterone and Bmi in Sudanese Women with Polycystic Ovary Syndrome en_US
dc.type Publication en_US
dc.Faculty Medical Laboratory Sciences en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account