University of Khartoum

Topical Herbal Emulgel for Psoriasis Treatment

Topical Herbal Emulgel for Psoriasis Treatment

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Title: Topical Herbal Emulgel for Psoriasis Treatment
Author: Eltahir, Eram Kamal Eldin Hussein
Abstract: Background: Psoriasis is a chronic, painful, autoimmune inflammatory skin disease. It affects men and women of all ages, with an incidence ranging between 0.09% and 11.4%. The disease is characterized by rapid hyperproliferation leading to redness, itchy white silvery scales, causing great physical, emotional, social burden and depression. Psoriasis is symptomatically treated by a range of oral, topical and intravenous medications. Major side effects in some cases were reported this. The aim of this work is to formulate topical preparations incorporating plant extracts of 50% aqueous coffee extract, Myrrh alcoholic extract, Cymbopogon proximus (volatile oil), Nigella sativa seeds total oil, Olibanum alcoholic extract and Theophyllin, that treat the psoriatic process from its different disorders in form of emulgel to delivering hydrophobic drugs with low cost and ease of application without greasiness. Hence, better therapeutic efficacy and improvement of patient compliance is achieved. Methods: Eight formulae were prepared containing different extracts with different concentration of carbopol 940. Four formulae (E1), (E2), (E3) and (E4) contain: 50% aqueous coffee extract, Myrrh alcoholic extract, Cymbopogon proximus (volatile oil), Nigella sativa seeds total oil and Olibanum alcoholic extract, the concentration of carbopol 940 range from (0.4-1.2g). Another four formulae (R1),(R2), (R3) and (R4) contain Myrrh alcoholic extract, Olibanum alcoholic extract and Theophyllin, the concentration of carbopol 940 range from (0.2-1.5g). All formulation were evaluated for physical parameters, viscosity, type of emulsion formed, average globule sizes, spreadability, diffusion studies, along with short term stability studies for selected emulgels at 22 ºC, RH 60% and at 45 ºC, RH 75%, conditions for three month.. Skin irritation and in-vivo anti-psoriatic activity using perry scientific mouse tail model also done for selected emulgels. Results: All emulgel formulations were physically acceptable, with good spreadability. Carbopol concentrations have direct influence on viscosity and release of the active ingredients. The average globule sizes ranged between 171.6 – 592.7 d.nm, pH of all formulated emulgels ranged between 5.63- 7.44, which are in the range of the normal skin pH. Rheograms revealed that all formulated emulgels exhibited non- Newtonian behaviour with pseudoplastic properties. Optimized formulations were (E1) and (R3) that showed 77.60% and 97.16% mean cumulative %release respectively after 480 minutes. (E1) and (R3) emulgels had good stability for 3 months. No skin irritation was noticed. Anti-psoriatic activity study showed that (E1) emulgel decreased the number of nucleated cell which shows significant increase in % orthokeratosis (p < 0.0001) compared to control group while, (R3) showed lower effect compared to (E1). Conclusion: The formulated (E1) emulgel (contains: 50% aqueous coffee extract, Myrrh alcoholic extract, Cymbopogon proximus (volatile oil), Nigella sativa seeds total oil and Olibanum alcoholic extract) is promising new herbal formula to treat psoriasis, also (R3) had anti-psoriatic effect but lower than (E1).
URI: http://khartoumspace.uofk.edu/123456789/26557


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