University of Khartoum

Adnexal Tumors Reported By the National Public Health Laboratory Khartoum (2012—2016)

Adnexal Tumors Reported By the National Public Health Laboratory Khartoum (2012—2016)

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Title: Adnexal Tumors Reported By the National Public Health Laboratory Khartoum (2012—2016)
Author: Naiel, Alaa Abdelaziz Hassan
Abstract: Background: Tumors of skin adnexae are an uncommon group of neoplasms that have not been formally studied in our locality. Adnexal tumors share many features in common and differentiate along one line. Their detailed morphological classification is difficult because of the variety of tissue elements and patterns are seen. They have been classified based on differentiation towards hair follicle, sebaceous, apocrine or eccrine glands. We undertook this study to determine the occurrence of skin adnexal tumors and the histopathology of these neoplasms and to correlate with age, sex, and location. Materials and Methods: This is a retrospective, prospective study conducted during a period of 5 years (2012-2016) on skin adnexal tumors received at National Health lab, Khartoum, Sudan. The relevant clinical profile was recorded. Histopathological examination was carried out on sections obtained and stained with H&E. Results: Eighty cases of adnexal tumors were diagnosed during the study period; the majority were benign 69/80(86.2%), and 11/80(13.8%) were malignant tumors. The commonest age group was between 21 and 40 years (33.75%) with a mean age of 45 years. Overall male: female ratio was 1: 1.2. According to the line and direction of differentiation, the most common histopathological origin of adnexal tumors was of sweat gland origin 47/80(58.7%). Eccrine sweat gland tumors formed about 38 (47.5%), and the remaining 9 (11.2%) were apocrine in nature. The benign sweat glands tumors constituted the majority of these tumors 44/47, distributed mainly on the extremities and head and neck region. Tumors originated from hair follicles constituted about 15\80 (18.8%), followed by Sebaceous tumors 14/80 (17.5%). Sebaceous neoplasms were more common in males 11/14. Among the mixed tumors type 4 cases of chondroid syringoma were diagnosed, all behaved in a benign fashion. Skin adnexal tumors were presented mainly as a single nodule (65%), ulcer (%18) and single papule (11%). These tumors were most commonly located in head, neck, and face (52.5%), followed by extremities (35%) and trunk (8.8%). Conclusion: Adnexal skin tumors are relatively rare tumors. The morphological assessment was the most important criteria in the diagnosis of these tumors and so a clear knowledge of the clinical presentation and histomorphology of these tumors is essential to make a correct diagnosis.
Description: 75 Pages
URI: http://khartoumspace.uofk.edu/123456789/26589


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