University of Khartoum

Organogenesis and Histogenesis of the Mesonephros and Metanephros of the Foetus of the One- humped Camel (Camelus dromedarius)

Organogenesis and Histogenesis of the Mesonephros and Metanephros of the Foetus of the One- humped Camel (Camelus dromedarius)

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Title: Organogenesis and Histogenesis of the Mesonephros and Metanephros of the Foetus of the One- humped Camel (Camelus dromedarius)
Author: Bashir, Sabah Omer Elgozouli
Abstract: The objectives of this investigation were to study the morphology and histochemistryof the mesonephros and metanephros in the camel foetus using standard techniques. A total of 73 foetuses (30 males and 43 females) of dromedary camel (Rashaidi, Bishari and their crosses) their ages ranged between 71 and 426 days were collected from Tambool slaughter point, preserved in standard international fixatives and divided into three groups according to their age. The curved crown rump length (CVRL) equation Y = 0.366X - 23.99 was used to determine the age of the foetus (x) in days from the known (y) CVRL in centimeter. The result showed that, the mesonephros changed its shape, size and position within the time of gonad differentiation due to its division into cranial and caudal portions in female foetuses between 10and 11 weeksof age and between 13and 14 weeks of age in male foetuses. The cranial portion regressed in female foetuses, but retained in male foetuses. The paramesonephric duct (Müllerian duct) was suppressed rapidly in male foetuses, while both the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts persisted in female foetuses till the time of total mesonephros regression. The mesonephros consisted of small and large renal corpuscles and two types of tubules in 71 days old foetuses. The large renal corpuscles were observed immediately before the time of differentiation into male or female gonads in foetuses between 71 and 74days old foetuses. In male foetuses, the large renal corpuscles occupied the cranial part of the mesonephros, while in female foetuses they were found near the hilus region. The diameter of the large renal corpuscles of the mesonephros ranged between 400µm and 450 µm with an average of 425 µm, whereas the diameter of the small renal corpuscles ranged between 100 and 120 µm with an average of 110 µm. The diameter of mesonephros tubules ranged between 20 and 60 µm with an average of 40 µm. The mesonephros regressed in female foetuses at the end of the 4th month of gestation and during the 5th month of gestation in male foetuses. Mucopolysacharides were found in the interstitial tissue of the mesonephric tubules and in their microvilli. Alkaline phosphatase activity was detected in the lining epithelium of the mesonephric tubules and in the wall of blood vessels. The primary tissue of the metanephros was first observed in foetuses between 71 and 74days old foetuses. The metanephros was lobulated in 126days old foetus, and this lobulation disappeared at 339 days of age. The ampullae developed from the collecting ducts starting at 74 days old foetus and continued up to 339 days old foetus. The renal corpuscles of the metanephros were in different stages of development from 74 days old foetus up to 339days old foetus. The podocytes began to establish their characteristic complex cell architecture during first trimester. The distal convoluted tubules were differentiated before the proximal convoluted tubules. The metanephric capsule thickness ranged between 10 and 12 µm with an average of 11 µmduring first trimester, 13 and 37 µm with an average of 25 µm during second trimesters and between 41 and 47 µm with an average of 44 µm during third trimester. The diameters of the metanephric proximal and distal convoluted tubules ranged between 8 µmand 14 µm with an average of 11 µmduring first trimesterand between 20µm and 40µm with an average of 30 µm during second and third trimesters. The diameter of the metanephric renal corpuscles ranged between 110 and 160µm with an average of 135µmduring the first trimester and decreased during second and third trimesters and ranged between 100 and 140 µm with an average of 120 µm and between 50 and 70 µm with an average of 60 µm respectively. The thickness of the cortex during first trimester ranged between 2 and 3mm with average of 2.5mm, and increased during second and third trimestersto measure between 3 and 5mm with an average of 4 mm and between 4 and 5 mm with average of 4.5mm respectively. The thickness of the medulla during first trimester ranged between 8 mm and 12 mm with an average of 10 mm and increased during second and third trimesters and ranged between 15 mm and 20 mm with average of 17.5 mm and between 20 and 25 mm with average of 22.5mm respectively. The ratio of the thickness of the cortex to the medulla during first trimester was 1:1, during second trimester was 1:1.5 and during third trimester was 1:4-5. Mucopolysacharideswere observed in the basal lamina of the convoluted tubules and in the microvilli of the proximal convoluted tubules. Glycogen particles were distributed in the cytoplasm of the cells lining straight collecting tubules and increased with advancement of gestation. Alkaline phosphatase activity was detected in the interstitial tissue of the renal corpuscles, the cells lining the straight tubules, the interstitial nephrogenic cells, the epithelium and the interstitialtissue of the convoluted tubules, the wall of blood vessels, adipose tissue, the interstitialtissue of the ampullae of collecting ducts and the metanephric capsule. In conclusion: The development of the mesonephros and the metanephros of the one-humped camel is slightly different from the development of other domestic animals.The transient lobulation which occurred in the metanephros of the dromedary camel foetuseswas similar to that in human.The metanephros of the dromedary camel foetus is characterized by wide medulla, narrow cortex, long loops of Henle, long proximal and distal tubules, long collecting tubule andsmall renal corpuscles.The important basic information included in this study will lead to a better understanding of any malformation which will result in physiological and pathological disturbances.
URI: http://khartoumspace.uofk.edu/123456789/26601


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