University of Khartoum

Synthesis of Gold Nanoparticles Using Natural Mixed Plants Extracts and Their Applications in Laser Phototherapy

Synthesis of Gold Nanoparticles Using Natural Mixed Plants Extracts and Their Applications in Laser Phototherapy

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Title: Synthesis of Gold Nanoparticles Using Natural Mixed Plants Extracts and Their Applications in Laser Phototherapy
Author: Awad, Manal Ahmeid Gamelseed
Abstract: The aim of this study was to synthesize gold nanoparticles and to use them with photothermal therapy in the treatment of carcinoma cells. A developed technique which is a novel, quick, cost effective and environmental friendly was used for the synthesis of noble metal gold nanoparticles (Au NPs) using a mixture of Olea europaea fruit extract and Acacia nilotica fruit extract. Synthesize nanoparticle had different shapes viz spherical, rod and other irregular shapes with average size of 44.96 nm. The synthesized nanoparticles were characterized by UV-visible spectroscopy, zetasizer, fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) equipped with energy dispersive spectroscopy (EDS) and transmission electron microscopy (TEM). The synthesized Au NPs showed excellent cytotoxic activity against MCF-7, HCT-116 and HepG-2 cells, with IC50 for nanoparticles concentrations of 45.5, 37.2 and 40.6 µl respectively more than the extract. More preferably these synthesized nanoparticles are used with photothermal therapy using laser light in treatment of Ehrlich Ascites carcinoma cells which showed excellent anticancer activity. All these findings prove and suggest that the gold nanoparticles synthesized from mixture of Olea europaea fruit extract and Acacia nilotica fruit extract is a promising candidate for a wide variety of applications in pharmaceutical and biomedical fields as well as in nanomedicine.
URI: http://khartoumspace.uofk.edu/123456789/26735


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