University of Khartoum

HER2 Immunohistochemical Expression among Sudanese Female Patients Diagnosed with Endometrial Carcinoma at Two Centers in Khartoum State from January 2013 to October 2016

HER2 Immunohistochemical Expression among Sudanese Female Patients Diagnosed with Endometrial Carcinoma at Two Centers in Khartoum State from January 2013 to October 2016

Show full item record

Title: HER2 Immunohistochemical Expression among Sudanese Female Patients Diagnosed with Endometrial Carcinoma at Two Centers in Khartoum State from January 2013 to October 2016
Author: Mohager, Samah O.
Abstract: Background: Endometrial carcinoma (EC) is one of the major gynecological malignancies. It is a significant health problem in Sudan. Researches that clarify the different characters of this cancer are yet not well established in this country. Human epidermal growth factor receptor2 (HER2) is a protein that is overexpressed in a variety of cancerous tissues. The study aim is to characterize EC in Sudanese women in terms of age, histological types and HER2 expression. Methods: Sixty one cases of Sudanese female patients diagnosed with EC from January 2013 to October 2016 at National Public Health Laboratory and Soba University Hospital Histopathology Departments were targeted for the study and were characterized in terms of age and histological subtypes. Samples of reports and paraffin embedded tissue blocks were available for immunohistochemical study. A total of 54 cases have been processed. Haematoxylin and eosin stained microscopic slides of the samples were prepared at the laboratory of the Histopathology Department of Soba University Hospital and examined for verification of histological stratification. In addition, tissue sections were prepared on adhesive microscopic slides and studied for HER2 expression by immunohistochemistry using HercepTest (Dako, Glostrup, Denmark). Statistical analysis was done on the obtained data using Chi-Square test. Results: The commonest age group of EC was 50-69 years (62.30%), followed by 70 years and above (26.22%) and 30-49 years (8.20%) whereas no age data was available for 2 patients (3.28%). The most common histologic subtype of EC was conventional adenocarcinoma (75.41%) followed by papillary serous carcinoma (11.47%), carcinosarcoma (8.20%) and clear cell carcinoma (4.92%). Concerning HER2 expression, 92.59% of the cases were negative (0 or 1+) while 5.56% were equivocal (2+) and only 1.85% were positive (3+).VIII Statistically significant relation was detected between HER2 expression and histological subtypes (P value = 0.01) but the association between HER2 expression and tumor grade was insignificant (P value = 0.06). No significant correlation was observed between HER2 expression and lymphovascular invasion within the tumor (P value= 0.49). Conclusion: The commonest age group of EC is advanced age with the most common histologic subtype being conventional adenocarcinoma. Overexpression of HER2 is not, this uncommonness could be attributed to tumor biology, the existence of unrecognized HER2 isoform or poor quality of specimens. A prospective study in which strict preanalytical quality control measures are followed is recommended in order to obtain reliable HER2 expression results.
URI: http://khartoumspace.uofk.edu/123456789/27092


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account