University of Khartoum

Haematological Abnormalities Versus CD4 Count as Predictors of Disease Progression in Human Immunodeficiency Virus Positive Sudanese Patients.

Haematological Abnormalities Versus CD4 Count as Predictors of Disease Progression in Human Immunodeficiency Virus Positive Sudanese Patients.

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Title: Haematological Abnormalities Versus CD4 Count as Predictors of Disease Progression in Human Immunodeficiency Virus Positive Sudanese Patients.
Author: Mohammad, Thanaa Ali Hassan
Abstract: Background: HIV infection is accompanied by distinct haematological changes that impair the health and treatment of patients. These hematological changes can be a sign of the underlying immune status of the individual. CD4 counts are used to assess disease progression. The aim of this study was to evaluate the hematological parameters in relation to CD4 cell count of HIV infected patients as a potential predictor of disease progression as they are less costy and easily available in low resource settings. Methods: This was a descriptive cross-sectional study, conducted at the flow cytometry laboratory / Khartoum state in the period from May 2014 to July 2016. The study included all Sudanese HIV positive patients attending this laboratory during this period. A designated questionnaire inquiring demographic, clinical and laboratory data was used. The study included a total of 187 patients of whom 112 patients were on treatment and 75 patients were not on treatment . CBC and CD4 counts were done in all patients and the data obtained were analyzed statistically using SPSS program version 20. 2011. Results: Among the 187 HIV infected patients, 59% were males and 41% were females. The mean age was 39 years. Anemia occurred in 73(39%) and 62( 33%) had neutropenia. Thrombocytopenia was seen in 24(12.8% ) and pancytopenia in 7(3.7%). Eighty seven (46.5%) of patients had CD4 cell count below 200 cells /cmm. CD4 counts were significantly correlated with different types of cytopenias. There was no significant correlation between haematological cytopenias and decreased CD4 count in the patients who started treatment, In patients who did not start treatment there was significant correlation between anemia and neutropenia with decreased CD4 count. Conclusion: Haematological abnormalities are commonly seen in HIV infected individuals. In the present study, hemoglobin, neutrophil count and platelet count, were significantly related to the CD4 cell counts so they can be used as potential predictor of disease progression. All patients with HIV infection should be investigated on regular basis and treated accordingly for the hematological abnormalities.
URI: http://khartoumspace.uofk.edu/123456789/27121


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