University of Khartoum

The Effect of Administration Of Oxytetracycline During Early or Late Pregnancy on Progesterone Concentration and Gestation Period in Cross-bred Dairy Cows

The Effect of Administration Of Oxytetracycline During Early or Late Pregnancy on Progesterone Concentration and Gestation Period in Cross-bred Dairy Cows

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Title: The Effect of Administration Of Oxytetracycline During Early or Late Pregnancy on Progesterone Concentration and Gestation Period in Cross-bred Dairy Cows
Author: Mohammed, Maha Awad Abdelwahab
Abstract: The study was performed to assess the effect of injection of aqueous oxytetracycline (OTC), 5% or 20% during early or late pregnancy (10 cows each) on progesterone (P4) concentration and gestation period (GP). Forty (40) multiparous (3 - 4) cross-bred cows aged 3 – 8 years were used in this study (20 treated and 20 control). The pregnant treated cows were followed up until parturition. Also a questionnaire was designed to fifty clinician respondents regarding breed of cattle, concentration of OTC, nature of OTC, route of administration, dose, and treatment of sick pregnant cows, treatment of apparently healthy pregnant cows and induction of abortion. The results showed that 100% of veterinarians injected OTC 5% or 20% in different breeds of cattle. Eight percent (8%) used 5% OTC and 4% used 20% OTC during pregnancy in dairy cattle and 68% used both concentrations. All of the veterinarians mentioned that they injected aqueous OTC (Alamycine, Norbrook, UK), 5% or 20% for treatment of sick cows and they injected the OTC 5% or 20% intramuscularly (I.M).22% injected the optimum dose of OTC (10 mg/kg) for four consecutive days in the pregnant cows and 78% used (20 mg/kg) and 82% of t injected OTC 5% or 20% for treatment of bacterial diseases in pregnant cows and the others (18%) injected OTC for treatment of viral and protozoan diseases in pregnant dairy cows. The vast majority (92%) of veterinarians did not inject OTC 5% and 20% for apparently healthy pregnant cows. Thirty eight (38%) of veterinarians indicated that injection of OTC 5% induces abortion in dairy cows, however, 62% did not ascertain this. Fifty two (52%) of veterinarians responded that injection of OTC 20% induces abortion in dairy cows, however, 48% had negative response. Three blood samples were collected from all pregnant cows (20 cows) after injection of OTC at 7 days intervals and assayed for progesterone (P4) concentration. The P4 concentration was insignificantly different compared to the control cows when OTC 5% was injected during early pregnancy. The mean value of P4 concentration of the cows treated with OTC 5% and the control (4.75 ng/ml and 4.72 ng/ml respectively). The P4 concentration was insignificantly different compared to the control cows when OTC 5% was injected during late pregnancy. The mean values of P4 concentration for the cows injected with 5% OTC during late pregnancy and the control were (12.12ng/ml and 11.99ng/ml), respectively. The P4 concentration was insignificantly different for the cows injected with OTC 20% during early pregnancy compared to the control. The mean values of P4 concentration of the cows injected with 20% OTC during early pregnancy and the control were (4.80 n g /ml and 4.72 ng/ml), respectively. The P4 concentration of the cows injected with OTC 20% during late pregnancy was insignificantly different compared to the control. The mean values of P4 for cows injected with OTC 20% and control cows are (12, 01 ng/ml and 11.99 ng/ml), respectively. The gestation period (GP) of cows injected with OTC 5% during early pregnancy (274.6 days) was not significantly different compared to the control (276, 6 days). The GP of the cows injected with OTC 5% during late pregnancy (276, 8 days) was not significantly different compared to the control (276, 6 days). The GP of the cows injected with OTC 20% during early pregnancy (275, 0 days) was not significantly different compared to the control (276, 6 days). The GP of cows injected with OTC 20% during late pregnancy (275, 4 days) was not significantly different compared to the control (276, 6 days). In conclusion, administration of aqueous short or long acting OTC during early or late stages of pregnancy in dairy cows is safe and does not influence gestation period.
URI: http://khartoumspace.uofk.edu/123456789/27169


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