dc.description.abstract |
In Sudan, some medicinal plants, such as Acacia seyal, Calotropis procera, and Balanites aegyptiaca, have
been used to prevent or treat oral health problems. The stem and stem bark of Terminalia laxiflora Engl.,
Combretaceae, are used as antiseptics for mouthwash to prevent gingivitis and thrush in Africa. Methanol
and 50% hydroethanolic extracts of 25 plants that are used in traditional Sudanese medicine for several diseases and cavity disorders were screened for anti-cavity activities. T. laxiflora methanolic wood
extracts, which exhibited such activity, were investigated. The crude extracts were assayed for their
antimicrobial activities against Streptococcus sobrinus in terms of minimum inhibitory concentration and
glucosyltransferase inhibition. The active extract of T. laxiflora wood was subsequently fractionated by
different chromatographic techniques. Isolated compounds were identified by spectroscopic methods
and assessed for S. sobrinus and glucosyltransferase inhibitory effects. Methanolic extracts of Terminalia brownii Fresen. (bark), T. laxiflora Engl. (wood), A. seyal Delile (bark), Persicaria glabra (Willd.) M.
Gómez (leaves) and Tamarix nilotica (stem) showed good activities against both S. sobrinus and glucosyltransferase (MIC ≤ 1 mg/ml, IC50 values <50 g/ml). Over all plant extracts, T. laxiflora demonstrated the
good combined activities (MIC 0.5 mg/ml, glucosyltransferase, IC50 10.3 g/ml); therefore, its methanolic wood extracts were selected for further phytochemical studies. Four constituents were isolated by
chromatographic techniques and identified by spectroscopic techniques. Pharmacological evaluation of
the obtained compounds showed that flavogallonic acid dilactone had comparatively good antibacterial activity. In the glucosyltransferase inhibitory test, terchebulin displayed potent activity with an IC50
of 7.5 M. The screening presented in this study showed that methanol extracts of T. laxiflora wood
possessed promising anti-cavity effects |
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