University of Khartoum

Screening for melanogenesis-controlled agents using Sudanese medicinal plants and identification of active compounds in the methanol extract of Terminalia brownii bark

Screening for melanogenesis-controlled agents using Sudanese medicinal plants and identification of active compounds in the methanol extract of Terminalia brownii bark

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Title: Screening for melanogenesis-controlled agents using Sudanese medicinal plants and identification of active compounds in the methanol extract of Terminalia brownii bark
Author: Yamauchi, Kosei; Mitsunaga, Tohru; Muddathir, Ali Mahmoud
Abstract: We isolated and identified compounds in medicinal plant extracts that could control melanogenesis. Sudanese medicinal plants were extracted with methanol (MeOH) and 50 % ethanol (EtOH)/water, yielding 104 extracts that were screened for melanogenic activity using B16 melanoma cells. The MeOH extract of Terminalia brownii bark dose-dependently enhanced intracellular and extracellular melanogenesis, with no cytotoxicity. Furthermore, we isolated and identified the components in T. brownii MeOH extract. Gallic acid (1), a,b-punicalagin (2), a,b-terchebulin (3), ellagic acid 4-O-a-L-rhamnopyranoside (4), ellagic acid (5), and 3,4,30-tri-O-methylellagic acid (6) were isolated by chromatography and identified using nuclear magnetic resonance (NMR), matrix-assisted laser desorption/ionization (MALDI) or ultra-performance liquid chromatography–time-of-flight mass spectrometry (UPLC–TOFMS), and ultraviolet (UV) spectroscopy data. Among the isolated compounds, 2, 3, 5, and 6 enhanced melanogenesis. Furthermore, compound 1 inhibited intracellular and extracellular melanogenesis with no cytotoxicity
URI: http://khartoumspace.uofk.edu/123456789/27176


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