University of Khartoum

Frequency of Iron Deficiency Anemia among Sudanese Women with Hereditary Bleeding Disorders

Frequency of Iron Deficiency Anemia among Sudanese Women with Hereditary Bleeding Disorders

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Title: Frequency of Iron Deficiency Anemia among Sudanese Women with Hereditary Bleeding Disorders
Author: Elshareef, Wafa Ahmed Abd Elsatir
Abstract: Introduction: Iron deficiency anemia is a common complication of chronic blood loss especially in patients with hereditary bleeding disorders. Women commonly present with menorrhagia but other bleeding symptoms can occur, therefore, evaluation of iron status is essential, and should be routinely done for symptomatic bleeders. The aim of this study is to assess the frequency of iron deficiency anemia among women with hereditary bleeding disorders and to correlate the haemoglobin level with iron status. Materials and Methods: This is a prospective cross-sectional descriptive study, conducted in Haemophilia Center of Khartoum Hospital. 30 women aged between 2 and 45 years diagnosed as bleeding disorders were studied. A questionnaire was used for the demographic data, bleeding symptoms and symptoms of anemia. Blood samples were taken for complete blood count, serum ferritin, serum iron and total iron binding capacity. Results: Of the 30 women investigated, 21cases (70%) were von Willebrand disease (VWD), 6 cases (20%) were other platelets fuction disorders, 1 case (3.3%) was glanzman’s thrombathenia, 1 case (3.3%) had combined FV-FVIII deficiency and 1case (3.3%) had FVII deficiency. Out of 30, 16 women were found to have hemoglobin (Hb), level less than 11 g/L, by definition anemic. 12 women with ferritin less than 14 μg/L, 21 women with serum iron less than 10μmol/L, 6 women with TIBC more than 75μmol/L. This study revealed that there was no significant relationship between Hb level and the abscentism from school and work among the study population (P value 0.9). There was no significant relationship between the severity of bleeding and the Hb level (P value 0.07), serum ferritin (P value 0.9) and serum iron (P value 0.9). 6 women were found to have low hemoglobin, serum ferritin, serum iron and high TIBC. According to that, the frequency of iron deficiency anemia was 22.2%. Conclusion: Iron deficiency anemia was found to be common among patients with hereditary bleeding disorders in this study with a frequency of 22.2%. More than half of anemic women had moderate to severe menorrhagia. Assessment of iron status and follow up of Hb level should be part of regular follow up of these patients. Iron supplement should be prescribed for any women with significant bleeding for at least 6 months.
URI: http://khartoumspace.uofk.edu/123456789/27445


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