University of Khartoum

In-Vivo Study of Drug-Resistant Trypanosoma Evansi Isolated From Naturally Infected Camels in Sudan

In-Vivo Study of Drug-Resistant Trypanosoma Evansi Isolated From Naturally Infected Camels in Sudan

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Title: In-Vivo Study of Drug-Resistant Trypanosoma Evansi Isolated From Naturally Infected Camels in Sudan
Author: Abdelgadir, Atif Elamin; Abdel Rahman, Mubark; Elrayah, Intisar; Elmalik, Khitma
Abstract: A total of 126 mice were used to study drug resistance on 13 isolates of Trypanosoma evansi collected from Butana, Gadarif and Southern Kordofan state against Quinapyramine sulphate and Cymelarsan. For Quinapyramine sulphate 36 mice (6 control and 6 tested group for each state) were used (the drug was given S/C), the results revealed that the isolates were very sensitive in Southern Kordofan state (6 mice were cured), however, the isolates showed resistance to the drug in all mice (12 mice) infectedwith T. evansi in Butana and Gadarif state. Regarding Cymelarsan 36 mice (6 control and 6 tested group for each state) were used (the drug was given S/C), the results showed that the isolates were very sensitive in Southern Kordofan and Gadarif state ( all mice were cured), but the isolates showed some degree of resistance in Butana (4 out of 6 isolates were cured). Quinapyramine sulphate killed 18 mice infected with T. evansi (6 mice for each state) when the drug was given intapretoneal. Double dose was used for assessing drug resistance against Quinapyramine on 36 mice (6 control and 6 tested group for each state) infected with T. evansi from Butana, Gadarif and Southern Kordofan state, the result revealed that 18 mice (6 mice for each state) were died.
URI: http://khartoumspace.uofk.edu/123456789/27707


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