University of Khartoum

One Health and a blood meal – integrative and ecologically sensitive approaches to mosquito-borne disease control

One Health and a blood meal – integrative and ecologically sensitive approaches to mosquito-borne disease control

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dc.contributor.author Haider, Najmul
dc.contributor.author Abdel Hamid, Muzamil Mahdi
dc.contributor.author Vairo, Francesco
dc.contributor.author Montaldo, Chiara
dc.contributor.author Sindato, Calvin
dc.contributor.author Mboera, Leonard
dc.contributor.author Yavlinsky, Alexei
dc.contributor.author Elton, Linzy
dc.contributor.author Arruda, Liã Bárbara
dc.contributor.author McHugh, Timothy D
dc.contributor.author Ippolito, Giuseppe
dc.contributor.author Zumla, Alimuddin
dc.contributor.author Kock, Richard
dc.date 2020
dc.date.accessioned 2020-12-24T11:55:19Z
dc.date.available 2020-12-24T11:55:19Z
dc.date.submitted 2020
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/27933
dc.description.abstract The objective of this article is to discuss available strategies on Mosquito-borne diseases (MBD) control in the present age. The key outcome of this review is that new approaches are urgently required, as insecticide resistance has become more prevalent in recent years with at least one of the four major classes of insecticides reported ineffective in 80% of malariaendemic countries. There is no single solution for MBDs. Recent promising initiatives to control MBDs targeting mosquitos include the use of insecticide impregnated mosquito nets, bacteria Wolbachia for biological control of Aedes-borne diseases and gene-editing of Anopheles gene edtiting using CRISPR-Cas 9 and mass drug administration of ivermectin for malaria control. Mosquitoes infected with Wolbachia have reduced ability to transmit viruses including dengue, Chikungunya and Zika. Reduction in incidence between 71 and 90% of dengue cases in Australia, Brazil, Indonesia and Viet Nam was reported. A recent study showed successful gene editing of the malaria vector Anopheles gambiae leading to complete sterility and total collapse in 7-11 generations. Wolbachia mediated vector control seems to be the current-best implementable non-invasive technology for Aedes related diseases control. Integrated vector management still appears the best option to combat the vectors and MBDs globally. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject One Health ; a blood meal ; integrative and ecologically sensitive approaches; mosquito-borne disease control en_US
dc.title One Health and a blood meal – integrative and ecologically sensitive approaches to mosquito-borne disease control en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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