University of Khartoum

The distribution of haptoglobin phenotypes among patients with some infectious diseases in Sudan

The distribution of haptoglobin phenotypes among patients with some infectious diseases in Sudan

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Title: The distribution of haptoglobin phenotypes among patients with some infectious diseases in Sudan
Author: Baleela, R. M. H.
Abstract: The major tropical diseases, other than malaria, in Sudan are: tuberculosis, widely distributed, schistosomiasis in central and western parts, visceral leishmaniasis in eastern and southern Sudan, trypanosomiasis in the southern andonchocerciasis in southern, northern and eastern regions. In this study haptoglobin phenotyping was performed using the electrophoresis separation of sera or plasma on polyacrylamide gel followed by benzidine staining to detect whether there is a relationship between haptoglobin phenotypesand susceptibility to the above-mentioned diseases. The distribution of the haptoglobin phenotypes (1-1), (2-1), and (2-2) among 59 subjects infected with tuberculosis, was found to be 27.1%, 50.8%, and 22.0% respectively. Among 46 subjects infected with intestinal schistosomiasis, it was foundto be 76.1%,21.7%, and 2.2% respectively. Among 188 subjects infected with visceral leishmaniasis, it was found to be 63.8%, 34.0%, and 2.1% respectively. Among 89 subjects infected with trypanosomiasis, it was found to be 68.5%, 22.5%, and 9.0% respectively. Among 37 subjects infected with onchocerciasis,it was found to be 43.2%, 45.9%, and 10.8% respectively. The results indicated that the number of individuals with Hp 1-1 was significantly higher among patients infected with protozoal parasites and schistosomiasis when compared to the controls, while no significant difference was seen when tuberculosis and onchocerciasis were concerned. Therefore it is reasonable to suggest that Hp 1-1 might be associated with the susceptibility to visceralleishmaniasis, trypanosomiasis, and intestinal schistosomiasis. A significant difference was found in the distribution of haptoglobin phenotypes between subjects with parasitic infections (except onchocerciasis) and subjects with bacterial infection (P= 0.000). No significant difference was detected betweenthe haptoglobin phenotypes and sex.
URI: http://hdl.handle.net/123456789/596
Date: 2002


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