University of Khartoum

Patterns of Extra-Pulmonary Tuberculosis in Adult Sudanese Patients

Patterns of Extra-Pulmonary Tuberculosis in Adult Sudanese Patients

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dc.contributor.advisor Prof. Abdel Gadir Mohammed Yousif Al kadaru en_US
dc.contributor.author Osman, Mohammed
dc.date.accessioned 2015-03-29T08:22:09Z
dc.date.available 2015-03-29T08:22:09Z
dc.date.issued 2015-03-29
dc.date.submitted 2004-04
dc.identifier.uri http://hdl.handle.net/123456789/7622
dc.description 120 page
dc.description.abstract Tuberculosis is found worldwide, but it is particularly common in Africa and Asia. The prevalence of tuberculosis increases with poor social conditions, inadequate nutrition and over crowding. The impact of tuberculosis in the developing world has been magnified in the past 20 years by the emergence of HIV pandemic(10). This study is carried out as trial to evaluate the clinical presentations of extra pulmonary tuberculosis, to 8 assess methods used in the diagnosis, and to identify factors that may predispose to the disease. In this study 100 patients of different types of extra-pulmonary TB were enrolled. Abdominal TB was found to be the commonest (37%), followed by tuberculous lymphadenitis (20%). TB of the skeleton and that of the pleura accounted to (19%) and (9%) respectively, while CNS TB was found in (4%) of the study. Genitourinary, pericardial and miliary TB each was observed in (3%) of the cases. Cutaneous TB was the least encountered, occurring in only 2 of the 100 patients. Clinical manifestations generally depend on the organ involved in addition to the general symptoms such as fever, weight loss and night sweat. Ascites was the commonest presentation of abdominal TB whereas enlarged lymph nodes with or without sinus formation were the commonest presentation of tuberculous lymphadenitis. 9 Affection of the dorsal spine with or without kyphos formation was the remarkable feature of spinal TB. Pleural tuberculosis presented mainly with unilateral pleural effusion. Signs of space occupying lesion were the main mode of presentation of CNS tuberculosis as well as tuberculous meningitis. Pericardial tuberculosis presented with effusion in two patients while in one patient it presented with constrictive pericarditis. In most patients the diagnosis was made on clinical grounds in addition to the presence of a high ESR and a positive Mantoux test as well as other specific investigations such as ascitic, pleural, pericardial and cerebrospinal fluids analysis. Tissue histopathology was obtained in a minority of patients (38%) and in all of them it showed the specific features of tuberculosis. Most patients did not receive BCG vaccination. HIV screening test was done for 56 patients and it was positive in 18 of them. Pulmonary tuberculosis can co-exist although not commonly with extra-pulmonary TB and in fact 10 sputum for acid alcohol fast bacilli was positive in 4 of the enrolled cases. en_US
dc.language.iso en_US en_US
dc.publisher UOFK en_US
dc.subject TUBERCULOSIS,National Tuberculosis Program (NTP),Extra-Pulmonary Tuberculosis en_US
dc.title Patterns of Extra-Pulmonary Tuberculosis in Adult Sudanese Patients en_US
dc.type Thesis en_US
dc.Degree M.Sc en_US
dc.Faculty MEDICINE en_US

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