University of Khartoum

Evaluation Of Azithromycin In Treatment Of Avulgaris

Evaluation Of Azithromycin In Treatment Of Avulgaris

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Title: Evaluation Of Azithromycin In Treatment Of Avulgaris
Author: IBRAHIM, SALAH ELDIN
Abstract: Acne vulgaris is the most common dermatological disorder in adolescence. As a matter of fact no individual transit through adolescence with out a few comedones and papules. Treatment is essential to prevent physical and psychological effects scarring occurred; acne is frequently associated with profound emotional aspects and depression. Although many treatments for acne are available, effective management has become increasingly challenging with the emergence of antibiotic-resistant strains of Propionibacterium acnes. Also systemic antimicrobial agents currently used such as doxycycline and erythromycin to reduce the inflammatory acne they require frequent administration for a long term therapy and some times associated with uncomfortable side effects contributing mainly to a decrease in compliance. Of-late, newer macrolide azithromycin circulated in Sudan market expected to show promising results in this condition due to its unique pharmacokinetic profiles and high thermodynamic properties and penetrative potentials . This study was conducted to evaluate the role of azithromycin in treatment of acne vulgaris. The present study was conducted in Omdurman teaching hospital – department of Dermatology. The main aim of this study is to evaluate the efficacy of oral azithromycin in acne by comparing it with most common therapy used for acne; doxycycline. An opened label randomized comparative study was carried out in (30) patients of moderate to sever acne vulgaris divided them into two groups, group (A) administered azithromycin capsules (15) in a specified and scheduled dose regimen and group (B) administered doxycycline tablets (15)as a usual regimen of therapy. The results obtained from oral azithromycin therapy when compared with oral doxycycline show that statistically there is no difference between the two drugs in response at end of 22 weeks. The overall efficacy rated in terms of reduction of the severity of condition is up to 83% with azithromycin compared to 50% with doxycycline In assessment of adverse effects and dropped-out rates the higher dropped- out rate found in doxycycline group (33.3%) while only (6.66%) for azithromycin group. Also the patients opinion as an outcome measuresmost of them confirm that they feel much better with azithromycin rather than doxycycline. Another minor complementary trial was adopted and we tried a topical formulation of azithromycin emulsion in 10 patients of mildto moderate acne but the results didn’t encourage us to continue due to the skin irritation from the vehicle used. The conclusion from the present study that oralazithromycin provides additionally effective and safe treatment option to the patients,and benefits may be further extended to those patients not responding to available antibiotic therapy. For the topical application of azithromycin the trial suggests that the need for further investigation and larger studies to find out a suitable vehicle and stable formulation for azithromycin to be applied topically and to determine whether it will give any significant results and have any advantages over the currently used topical formulatio
Description: 165 page
URI: http://hdl.handle.net/123456789/8224
Date: 2015-04-04


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