University of Khartoum

Radiological Bone Manifestation of Sickle Cell Anaemia in Sudanese Patients

Radiological Bone Manifestation of Sickle Cell Anaemia in Sudanese Patients

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Title: Radiological Bone Manifestation of Sickle Cell Anaemia in Sudanese Patients
Author: Mohemed;Manal Mohemed Kamal
Abstract: Sickle cell anaemia (SCA) is a disease caused by production of abnormal haemoglobin, which binds with other abnormal haemoglobin molecules within the red blood cell to cause rigid deformation of the cell. This deformation impairs the ability of the cell to pass through small vascular channels, sludging and congestion may result, followed by ischaemia and infarction of the tissue. This is a descriptive hospital-based study which was conducted in the Sickle Cell Clinic and Khartoum Teaching Hospital in Khartoum State in Sudan.One hundred patients with SCA were included in this study. The study was carried out in the period from April 2003 to January 2004. All the patients were investigated by plain radiography for the lateral skull, spine, and limbs. The vast majority of the patients (98%) presented once at least with acute painful crisis. While 48 patients presented with additional presentations such as chest infection, jaundice ..etc. Most of the patients (62%) presented for the first time at the age range of 6-12 months. The skeletal plain films radiography showed that the limbs were affected more (31%) in the form of decreased bone density and mixed density and soft tissue involvement, followed by spine affection (25%) in the form of decreased bone density (25 patients) and vertebral end plate central depression. The radiographic films showed that (9%) of skulls were affected in the form of decreased bone density in 6 patients and increased bone size in 9 patients (widened diploic space). The radiological films of the lower limbs of 5 patients showed bone infarction while 2 films showed signs of secondary infection. There is no direct correlation between clinical symptoms and radiological findings.
Description: 84 Pages
URI: http://khartoumspace.uofk.edu/handle/123456789/8341
Date: 2015-04-06


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