University of Khartoum

Analysis of some Pharmaceuticals utilizing Sequential Injection and Differential Electrolytic Potentiometry

Analysis of some Pharmaceuticals utilizing Sequential Injection and Differential Electrolytic Potentiometry

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Title: Analysis of some Pharmaceuticals utilizing Sequential Injection and Differential Electrolytic Potentiometry
Author: Eldaw, Atta Elmanan
Abstract: The objectives of this study is to perform comprehensive procedures for the oxidation of chlorpheniramine maleate and verapamil hydrochloride by permanganate in sulphuric acid media utilizing sequential injection analysis (SIA) and promethazine hydrochloride by cerium IV in acid medium using differential electrolytic potentiometry (DEP). To construct SIA and DEP manifolds suitable for these methods ofassay. To establish appropriate programs to control the newly adopted methods. To search for the optimum conditions for these assay methods, to conduct a chemometric optimization for the SIA methods, to evaluate the accuracy, precision, repeatability, robustness and cost of the newly adopted method, and finally to validate the newly adopted methods by comparison with the BP standard methods. In this thesis two systems were studied, the first was sequential injection analysis (SIA) technique for the assay of chlorpheniramine maleate and verapamil hydrochloride in pharmaceuticals formulations, and the second was DEP (differential electrolytic potentiometry) for the assay of promethazine hydrochloride in pharmaceutical formulations.
URI: http://khartoumspace.uofk.edu/handle/123456789/8381
Date: 2015-04-07


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