University of Khartoum

Hepatoprotective Activity Of Selected Plants' Extracts In Sudan On Murine Induced-Liver-Damage

Hepatoprotective Activity Of Selected Plants' Extracts In Sudan On Murine Induced-Liver-Damage

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Title: Hepatoprotective Activity Of Selected Plants' Extracts In Sudan On Murine Induced-Liver-Damage
Author: Awad, Sumaia
Abstract: In the present study, the aqueous and methanolic extracts of Dobera glabra leaves and Capparis decidua stems (two Sudanese medicinal plants), were screened for their hepatoprotective activity against CCl4 –induced hepatotoxicity in rats. These plants are used in traditional system medicine in the treatment of jaundice; no systematic studies on their hepatoprotective activity have been reported before. The hepatotoxicity produced by administration of CCl4 in paraffin oil 1:9 at a dose of 0.2 ml/kg for 10 days, was found to be inhibited by simultaneous oral administration of aqueous and methanolic extracts of C. decidua stems and at a dose of 200 and 400 mg/kg for 10 days, with evidence of decreased level of serum aspartate amino transferase, alanine amino transferase, alkaline phosphatase and bilirubin. In addition the concurrent administration of both extracts with CCl4 for 10 days masked the liver fatty changes induced by the hepatotoxic compound observed in the control rats and comparable with the hepatoprotective effect of the standard drug silymarin. The aqueous and methanolic extracts of Dobera glabra leaves in two doses, did not affect either the elevated level of the hepatic enzymes induced by CCl4 or protectively from liver. Furthermore, the subchronic toxicological investigations were done to evaluate the adverse toxic signs and effects of the plant that possess hepatoprotective activity. A preliminary phytochemical screening of the powdered plants was also carried out.
URI: http://khartoumspace.uofk.edu/handle/123456789/8422
Date: 2015-04-07


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