University of Khartoum

Prevalence Of Hepatitis C Virus Antibodies Among Children With Chronic Renal Failure In Khartoum State

Prevalence Of Hepatitis C Virus Antibodies Among Children With Chronic Renal Failure In Khartoum State

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Title: Prevalence Of Hepatitis C Virus Antibodies Among Children With Chronic Renal Failure In Khartoum State
Author: Abd El Rahman, Hind
Abstract: Hepatitis C virus infection (HCV) is emerging as the world’s predominant cause of chronic liver disease. Variable prevalence of hepatitis C (HCV) infection has been reported in adult patients with chronic renal failure on renal replacement therapy. So we have studied the prevalence of anti- HCV infection in children in the renal units. The objectives of this study were to determine the prevalence of anti-HCV antibodies in patients with chronic renal failure, then to study the risk factors for acquiring HCV infection and to correlate the presence of anti-HCV antibodies to liver disease activity. Records were reviewed for demograghic, clinical, biochemical data and risk factors .Sera from 50 patients under going haemodialysis, peritoneal or conservative management and 50 control were tested for antibody to HCV by 3rd generation Enzyme – linked immunosorbent assay. From a total of 50 patients (33 male and 17 female), aged 0-18 yrs, two were anti-HCV positive (4.0%) All the anti-HCV positive patients had been on haemodialysis for a mean of 27 months, while the anti- HCV negative patients had been on dialysis for 15 months (p<0.003). All the anti-HCV positive patients had been transfused with 2-8 units, a mean of 5 units (p<0.000). No one of them has had prior or recent HBV or HIV infection. The most predictive risk factor for HCV infection was the length of time on haemodialysis.Three out of the 50 patients had high alanine amino transferase levels. Two were patients with chronic renal failure; one of them was positive while the other was negative for anti-HCV, the third one was in the control group with negative anti- HCV.
URI: http://khartoumspace.uofk.edu/handle/123456789/8453
Date: 2015-04-07


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