University of Khartoum

Study the Hydrolytic Degradation of Nicardipine Hydrochloride

Study the Hydrolytic Degradation of Nicardipine Hydrochloride

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dc.contributor.advisor PROFESSOR KAMAL AL-DEEN ELTAYEB IBRAHIM en_US
dc.contributor.author BASHIR, LATIFA
dc.date.accessioned 2015-04-07T19:33:33Z
dc.date.available 2015-04-07T19:33:33Z
dc.date.issued 2015-04-07
dc.date.submitted 2009
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/8472
dc.description.abstract Chemically, nicardipine is 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid methyl-2-[methylphenylmethyl) aminomethyl ester (Merck index 2001). The presence ofthe ester linkage in its structural formula renders it susceptible to hydrolysis by both acids and alkalies. The possible degradation of the drug under such conditions initiated the present study. Reviewing the literature, revealed that, only the effect of light on the stability of nicardipine has been studied. This led to study the degradation of this compound under normal and stress conditions such as elevated temperature, a hostel of chemical environment and a combination of these conditions. The aims of this work are : 1. Development of a stability-indicating HPLC method for nicardipine HCl and its degradation products. 2. To evaluate the kinetic parameters of the degradation reaction. 3. To gain knowledge on the mechanism of decomposition. 4. To isolate and identify the degradation product(s). 5. To indicate at what pH the drug is stable en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject HYDROLYTIC DEGRADATION,NICARDIPINE,HYDROCHLORIDE en_US
dc.title Study the Hydrolytic Degradation of Nicardipine Hydrochloride en_US
dc.type Thesis en_US
dc.Degree M.Sc en_US
dc.Faculty Pharmacy en_US
dc.contributor.faculty PHARMACEUTICAL CHEMISTRY en_US

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