University of Khartoum

Prevalence of anti–Plasmodium Falciparum Merozoite Surface Protein-119 (PfMSP1-19) Antibodies in Sudanese Pregnant Women atUmdurman Maternity Hospital.

Prevalence of anti–Plasmodium Falciparum Merozoite Surface Protein-119 (PfMSP1-19) Antibodies in Sudanese Pregnant Women atUmdurman Maternity Hospital.

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Title: Prevalence of anti–Plasmodium Falciparum Merozoite Surface Protein-119 (PfMSP1-19) Antibodies in Sudanese Pregnant Women atUmdurman Maternity Hospital.
Author: IBRAHIM, MANAL
Abstract: The polymorphic merozoite surface protein (MSP-1) of Plasmodium falciparum is a major asexual blood-stage malaria vaccine candidate. Immunological mechanisms responsible for eliminating malaria parasites remain unclear, but antibodies to the carboxyl-terminal 19-kDa segment of the MSP1-19 have been implicated. This study aimed to determine the prevalence of anti-MSP-119 antibodies in pregnant women. In a prospective, case-control study, antibody levels in pregnant and non-pregnant women were compared using bulk ELISA technique. Results showed that the antibodies levels to MSP-119 in pregnant women were lower compared to non-pregnant. Furthermore, multigravidae have higher anti- MSP1-19 antibodies levels compared to primigravidae. On the other hand, increasing prevalence of anti-MSP-119 antibodies with the increase in age in pregnant women could be detected. In conclusion: low anti- MSP1-19 could be a possible explanation for the increased pregnancy -associated malaria in pregnant women especially primigravidae.
Description: 54page
URI: http://khartoumspace.uofk.edu/handle/123456789/8576
Date: 2015-04-08


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