University of Khartoum

The Effect of Chronic Renal Failure on Hepatic Functions in Sudanese Patients

The Effect of Chronic Renal Failure on Hepatic Functions in Sudanese Patients

Show simple item record

dc.contributor.advisor Sumaia Abukashawa en_US
dc.contributor.author Ibrahim, Bedour
dc.date.accessioned 2015-04-08T11:09:57Z
dc.date.available 2015-04-08T11:09:57Z
dc.date.issued 2015-04-08
dc.date.submitted 2005-02
dc.identifier.uri http://khartoumspace.uofk.edu/handle/123456789/8602
dc.description 133 Pages
dc.description.abstract There is abundant evidence that animal studies in chronic renal failure show a major down regulation of hepatic cytochrome P450 metabolism and hepatic functions are reduced; however, direct evidence in humans is lacking. This study is carried out in the period from October 2003 to October 2004 and the purpose of it is to outline the effect of chronic renal failure on human hepatic functions. Liver functions in Sudanese patients with chronic renal failure were studied. Study subjects were 45 patients (11 females and 34 males) with chronic renal failure under regular heamodialysis (2 times per week) and 20 healthy persons (control). Blood samples were collected from the patients (pre-dialysis) and the controls in order to measure serum albumin, total protein, serum bilirubin levels as well as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase activities (ALP). Chronic renal failure patients exhibited a decrease in serum albumin level (p<0.05) while total protein level and alkaline phosphatase activity were increased (p<0.05). Chronic renal failure did not alter AST and ALT activities. Serum bilirubin levels were unaffected. From this study it is concluded that chronic renal failure has no clear effect upon the liver functions in humans and that it may be attributed to the positive effect of dialysis removal of toxins outside the body. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject Chronic Renal Failure,Hepatic,Functions, Sudanese Patients;Kidney structure;Chronic renal failure en_US
dc.title The Effect of Chronic Renal Failure on Hepatic Functions in Sudanese Patients en_US
dc.type Thesis en_US
dc.Degree M.Sc en_US
dc.Faculty Veterinary Medicine en_US
dc.contributor.faculty Biochemistry en_US

Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account