University of Khartoum

Effect of Piper abyssinica and Jatropha curcas Against Experimental Haemonchus contortus Infection in Desert Goats

Effect of Piper abyssinica and Jatropha curcas Against Experimental Haemonchus contortus Infection in Desert Goats

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Title: Effect of Piper abyssinica and Jatropha curcas Against Experimental Haemonchus contortus Infection in Desert Goats
Author: Abd El Raheem, Nawal
Abstract: The present study was run to evaluate the anthlmintic activity of Piper abyssinica and Jatropha curcasagainst experimental H. contortusinfection in desert goats. All the groups (A,B,C and D) were orally infected with a single dose of 125 third stage larvae of H. contortus.The powdered seed of Piper abyssinica(dosed at 500 and 1000mg/kg b.wt. for two consecutive days) produced 18.6 and 57.4% efficacy rates respect ively. The powdered seed of Jatropha curcas (dosed 250 and 500mg/kg bwt. for two consecutive days) produced 8.1 and 43.3% efficacy rates respectively. The powdered seed of Piper abyssinicadosages showed a significant reduction in worm numbers compared to the control group. The powdered seed of Jatropha curcasdosages also showed a significant reduction in worm number when compared to the infected control. The effectiveness of powdered seeds both of Jatropha curcasand Piper abyssinica was weaker than that produced by Ivermectin at a dose of 200 µg/kg. b.wt, comparatively the effectiveness of powdered seed of Piper abyssinicawas better than that of Jatropha curcas. The clinical signs inall infected groups were manifested by dullness, weakness, emaciation, diarrhoea and pale visible mucous membranes. After treatment, there were slight histopathological changes in Piper abyssinicagroups, slight congestion in liver, small intestine, kidney, severe congestion and haemorrhage in abomasums and haemosidrosis in the spleen. In groups that were treated with Jatropha curcasthere was slight congestion in kidney and abomusum and the spleen showed haemosiderin deposit. H. contortuseggs were detected in faces at days 17 and 18 post infection with maximum shedding at days 19 and 25. There were decreases in Hb, PCV and RBCs in the infected control while the valuesof these haematological parameters are significantly increased in the treated groups of the two plants. The biochemical alterations of infected control were characterized by reduction in total protein, albumin and iron concentrations whereasthese parameters were significantly increased in the treated groups of the two plants including the group that received Ivermectin.
URI: http://khartoumspace.uofk.edu/handle/123456789/8669
Date: 2015-04-09


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