University of Khartoum

Hepatoprotective Effects Of Some Medicinal Plants In Rats In Sudan

Hepatoprotective Effects Of Some Medicinal Plants In Rats In Sudan

Show full item record

Title: Hepatoprotective Effects Of Some Medicinal Plants In Rats In Sudan
Author: HASSAN, NUHA
Abstract: The hepatoprotective study of Raphanus sativusand Lepidium sativumseeds extracts was performed on rats in which liver damage was induced by carbon tetrachloride (CCL4). The oral administration of the methanolic and water extracts of Raphanus sativus (200 and 400 mg/kg) significantly reduced the CCL4 induced hepatotoxicity as indicatedby inhibition of increased serum AST, ALT and ALP activities and bilirubin concentration. The effect of methanolic and ethanolic extracts of Lepidium sativum (200and 400mg/kg) on liver damaged produced by CCL4was less evident as reflected by measurement of serum AST, ALT and ALP activities and bilirubin concentration and histopathological changes. Toxicity study of both plants revealed that Raphanus sativushad no adverse effect on liver while Lepidium sativumcaused mild vacuolation of hepatocytes. These results indicate that Raphanus sativusis more effective in the protection against CCL4-induced liver damage than Lepidium sativum.
URI: http://khartoumspace.uofk.edu/handle/123456789/8674
Date: 2015-04-09


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show full item record

Share

Search DSpace


Browse

My Account