University of Khartoum

Efficacy of Intravenous Magnesium in Acute severe Bronchial Asthma in adult attending Khartoum Emergency Hospitals

Efficacy of Intravenous Magnesium in Acute severe Bronchial Asthma in adult attending Khartoum Emergency Hospitals

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Title: Efficacy of Intravenous Magnesium in Acute severe Bronchial Asthma in adult attending Khartoum Emergency Hospitals
Author: Obeid, Khalid
Abstract: Background: studies of IV magnesium sulphate as a treatment for acute asthma have had mixed results with some data suggesting a benefit for acute severe asthma, but not for mild to moderate asthma. Design: single-blind controlled clinical trial. Setting: Emergency Departments (ED) of two hospitals (ElShaab and Omdurman Teaching Hospitals). Patients: patients aged 18 to 60 years presenting with acute severe asthma and PEFR < 50% predicted on arrival to the ED. Intervention: All patients received nebulized salbutamol at regular intervals, and IV hydrocortisone. Two grams of IV magnesium sulphate were randomly administered to 25 patients (out of 50) using computer randomization program or nothing 30 minute after ED arrival. The primary efficacy end point was PEFR at 240 minute. Results: Fifty patients were included and mean PEFR at ED arrival was 33.7% predicted. At 240 min, patients receiving magnesium had a mean PEFR of 65.1% predicted compared to V 48.2% predicted in those who did not received magnesium (CI 7.97 and 25.89) with P. < 0.005. In conclusion this study indicated that when 2 g MgSO4 is given as an adjunct to standardized asthma therapy to patients presented with severe acute asthma, there is significant improvement in clinical scenario and pulmonary function. Thus these would support routine use of MGSO4 in patients with severe acute asthma. So the study recommended for further larger multicenter studies, should support or talk more about the effect of MgSO4 on moderate to severe Sudanese asthmatic patients.
URI: http://khartoumspace.uofk.edu/handle/123456789/8737
Date: 2015-04-09


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