Growth and sexual maturation in children and adolescents with type I diabetes mellitus in Khartoum State

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Ibrahim, Samia
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Over the last 50 years the prognosis for growth and pubertal development in children with type one diabetes mellitus has improved. Considerably, however growth failure can occur in diabetic children with long standing poor glyceamic control. The aim of this study is to assess physical growth and pubertal Development in a group of children with type 1 DM of diabetic children and to evaluate the effect of duration of illness, and degree of glyceamic Control on growth and sexual maturation. Anthropometric measurement of height, weight, body mass index, pubertal status, as well as bone age were assessed in 138 children with Type1 DM aged, 1 – 17 years, treated in two diabetic centers, Thirty eight patients (27.5%) had stunted growth, defined as height for age < - 2 SD, fifteen of these patients were in age group 9 -17 years, growth failure was positively correlated with level of glycosylated hemoglobin (HbA1c) (P = 0.001), there was no gender predilection shown. Twenty four patients (14.4%) had moderate under weight defined as weight for age < -2SD, nine patients (6.5 %) had sever under weight, defined as weight for age <- 3SD. , under weight was positively correlated with level of glycosylated hemoglobin (P =0.002). V Thirty-two (23.2%) patients had delayed bone age, twenty nine of these patients were in age group 9 – 17years. Ten females (20%) and nine males (16.9%) of adolescents, shown delayed sexual maturation with positive correlation with poor glyceamic control. This study revealed growth retardation and delayed skeletal and sexual maturation in young Sudanese patients with insulin dependent diabetes mellitus, and emphasized the importance of strict glyceamic control.
Growth, sexual, maturation,adolescents,diabetes mellitus,