University of Khartoum

Evaluation of Screening Techniques for Diagnosis of Cancer of the Cervix

Evaluation of Screening Techniques for Diagnosis of Cancer of the Cervix

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Title: Evaluation of Screening Techniques for Diagnosis of Cancer of the Cervix
Author: Francis, Oromo
Abstract: Carcinoma of the cervix is the most common female genital cancer in Developing countries. About 500,000 women acquire the disease and about 75% are from developing countries annually. In Sudan cancer of the cervix is the second most killer cancer, next to breast cancer by 18%. Human papilloma virus infection among others is incriminated mainly in the development of cervical carcinoma. The objective is to evaluate the types of screening methods available in the Sudan. A cross-sectional study has been designed to evaluate the validity of Pap smear, Colposcopy and visual inspection of cervix using acetic acid in the diagnosis of cervical lesions in women of reproductive age. The study has been carried at screening centers in Khartoum which includes 31 patients. The main results indicate that most cases of cervical malignancies are common between the ages 31-40 by 45.2%. Hormonal drugs and /or contraceptives are related to the genesis of cervical cancer at a frequency of 45.2%. Vaginal discharge is the main symptom by 83.9% for cervical malignancies. Cervical ectopy is the main colposcopy finding by 66%. CIN I is found to be the most frequent cervical condition by 16.1%. Results of Visual Inspection Using Aceto-Acetic Acid (VIA) according to the nature of reaction showed VIA is 93.5% positive. In conclusion, visual inspection using 5 % acetic acid is found to be more sensitive and has a higher accuracy as compared to pap smear. Screening using VIA has been shown to be effective in screening for the cervical cancer with a sensitivity and specificity of 93.5% and 64%, respectively. I therefore recommend that VIA might hold the key to effective screening method in low resource areas of the Sudan, achieved by its high negative predictive value.
Description: 125 page
URI: http://khartoumspace.uofk.edu/handle/123456789/8925
Date: 2015-04-12


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