Effects Of Feeding Commercial Oil Of Nigella Satival. On Liver Function Test In Rabbits

Abstract

This work was conducted in the Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum to study effects of commercial oil of Nigella sativaL. on liver function test in rabbits. Twenty two healthy rabbits males and females, weighting between 700 and 1500 grams were selected. The experiment was conducted in rabbits treated with (0%, 2.5% and 5%) N. sativaoil mixed with their feed, for six weeks. Blood samples were collected before feeding experimental diets and then after three weeks and six weeks.The blood samples were taken from the marginal ear vein for investigations of Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Gammaglutamyltransferase (GGT), Total protein, Albumin and Total Bilirubin. The results revealed a significant decrease in the activity of Serum Aspartate transaminase (AST), Serum Alanine transaminase (ALT) and Serum Gamma-Glutamyltransferase (GGT) in all treated groups compared to the control group. In group (B and C) the level of Serum Alkaline Phosphatase a significantly (P<0.05) increased in the third week, but the level was decreased in sixth week. The level of total protein and total bilirubin concentration were decreased a significantly in all treated groups. Serum albumin concentration showedsignificantly (P<0.05) decreased IX levels in the treated groups in the sixth week compared to the control group. Group-B that received 2.5% N. sativaoil showed significant (P<0.05) increase in the sixth week.