University of Khartoum

Clinical and pharmacological investigation of a benzimidazole anthelmintic against donkeys’ worm infestation

Clinical and pharmacological investigation of a benzimidazole anthelmintic against donkeys’ worm infestation

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Title: Clinical and pharmacological investigation of a benzimidazole anthelmintic against donkeys’ worm infestation
Author: Mohmmed, Sawsan
Abstract: In this study we decided to throw light on some aspects of donkey’s helminthes infestation and control and the impact oftreatment on liver and kidney function. In this study, 1256 animals were examined, 446 horses (Equus cabalus) and 810 donkeys (Equus asinus) during the period October 2006 to September 2007, in South Darfur State, to investigate infection with gastro-intestinal nematodes. The overall prevalence of gastro-intestinal nematodes was 29.20%. November showed the highest incidence of infection (41.50%) while June the lowest incidence of infection (13.92%). The average arithmetic mean of egg per gram of faeces (epg) count was 589.97 ± 986.02 and the highest range reported was on April of 50-13450. The animals harbouring mildinfection reported the highest incidence of 81.35%, while moderate infection reported 8.11% and 10.54 for severe infection. The most prevalent genera of gastro-intestinal nematodes were Strongylus spp, Cyathostomes spp, Trichostrongylus spp, and Strongyloides westeri. Horses showed prevalence of 15.37%. In August showed we observed the highest incidence (100%), while in March was the lowest incidence (5.26%). Severity of infection reported were 82.35% for mild, 8.82% for moderate and 8.82% for severe infection. Arithmetic mean of egg per gram of faeces (epg) count was 975.37±1099 and the highest range reported on November of 50-13450. Donkeys showed 37.48% prevalence ofgastro-intestinal nematodes. In January we observed the highest incidence of 55.79%, while in May we reported the lowest incidence 14.89%. Severity of infection showed 81.25% for mild, 7.89% for moderate and 10.86% for severe infection. Arithmetic mean of egg per gram of faeces (epg) count was 750.14±1071.95 and the highest range reported was in April 50-11800. The therapeutic efficacy of Albendazole and Ivermectin drench formulation at the manufacturers recommended dose were evaluated in controlled trial at Nyala town, South Darfur State, Sudan. The study involved 24 donkeys naturally infected with gastrointestinalnematodes; they were divided into four groups of equal size. Albendazole was administered orally once at dose rate of 10 mg/kg body weight for group one (ALB1) and twice with interval of 14 days post treatment at the same dose rate of 10 mg/kg body weight for group two (ALB2). Ivermectin was administered orally as single dose at 200 µg/kg body weight for group three (IVMT), group four was left without treatment as a control. Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment. A faecal egg count reduction of 100% was found after treatment with Albendazole, Albendazole twice and Ivermectin. At necropsy efficacy percentages of Albendazole, Albendazole twice and Ivermectin against adult nematode were as follows: Trichostrongylus axei 67.09%, 100% and 100%; Parascaris equorum100%, 100% and 100%; Oxyuris equi 100%, 100% and 100%, Strongylus sp.98.4%, 100% and 98.81%; and small strongyles 91.7%, 99.5% and 96.5%. Albendazole, Albendazole twice and Ivermectin with the single dose showed low to moderate efficacy (33%, 48.84% and 62.71%, respectively) against larvae found the cranial mesenteric artery aneurisms. No adverse reactions were observed in treated donkeys during the experiment period. Blood samples were also collected from the above treated animals to examine the effect of treatment on different biochemical parameters. Blood samples were collected at day 0, 1, 3,7, 14 and 21 days post treatment, then serum biochemical analysis was conducted using commercial kits. Although, results obtained showed significant changes during some sampling times but all the values were within the normal rangesuggested by other researchers. All parameters tested were within the normal range by the end of the study.
Description: 109 Pages
URI: http://khartoumspace.uofk.edu/handle/123456789/9086
Date: 2015-04-18


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