Serriobiochemical Effects Of Sodium Nitrate In Rats

Abstract

The present study was carried out to investigate the effect of sodium nitrate on Wister Albino rats. Twenty rats were divided randomly into 4 groups, 5 rats each. Group A saved as control and group B, C and D were administrated orally with sodium nitrate (NaNO3) at a dose of 50, 100 and 200 mg/kg body weight (Bwt) respectively. There were no significant differences in body weights of treated groups compared to the control. However, the body weights of the control was increased at rate of 13.0%, while the rate of increase in body weights in groups (B) which was treated with 50 mg/Kg (Bwt) sodium nitrate was 3.4%. The increase in body weights of group (C) which was treated with 100 mg/Kg (Bwt) sodium nitrate was 1.8% and the increase in body weights of group (D) which was treated with 200 mg/Kg (Bwt) sodium nitrate was 4.15%. There were a significant reduction in the number of RBCs. Of the treated groups compared to the control. Hb concentration was significantly lower of treated groups compared to the control. There was significant decrease in PCV of treated groups compared to the control. Never the less there were significant increases in MCH value in treated groups compared to the control. There were significant decreases in total protein of treated groups compared to the control while the activity of ALP showed significant increase in the treated groups compared to the control. There was no significant different among the group in MCV, MCHC, Albumin and Globulin concentration in treated groups compared to the control.