Elimination, Distribution and Metabolism of Lindane (Gamma Hexachlorocyclohexane) in Male Goat

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Rihab Ali, El Fahal
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Elimination, distribution in tissues and metabolic degradation of lindane insecticide (gamma hexacWorocyclohexane) were studied in a male Nubian goat (Cappara aegagrus hircus). The goat was dosed orally with 262.76 mg 14C_ lindane equivalent to one fourth of its lethal dose (LD50). Urine and faeces were collected for two weeks following the application date and the radioactivity was measured in order to detennine the rate of the insecticide elimination from the animal body. Lindane elimination was found to be initially fairly rapid, principally via urine (19.6% of the applied dose was detected in urine and 3.1 % in faeces). However, it was observed that total recovery of the insecticide via faeces and urine is low. After two weeks, the animal was sacrificed and samples of the brain, liver, kidneys, heat, lungs, legs muscles, and abdominals fat were collected. The percentage of the total radioactivity detected in all the tissue samples was 0.29 % of the applied radioactive lindane. The fat contained 48.25% of this percentage, 29.78% was detected in the liver, 9.05% in the lungs and 8.72% in the heart. Smaller percentages were detected in the other tissues. Urine and faeces were extracted, analysed and their contents of lindane metabolites were identified using autoradiography. It was found that 23% of the labelled lindalle detected in mine was excreted unchanged. A no polar compound possibly a trichlorophenol represented 26% of the radioactivity detected in urine, while 51 % was represented in highly polar compounds and conjugates.
Elimination, Distribution and Metabolism of Lindane