Major Genetic Variants of Glucose 6 Phosphate Dehydrogenase among Selected Sudanese Ethnic Groups

Abstract

Background: The glucose 6 phosphate dehydrogenase (G6PD) gene is X chromosome linked, and the deficiency in this enzyme is the most common known enzymopathy in humans, and is usually, occurs due to single nucleotide substitution which varies from population to other, these mutations accounts for more than 400 variants worldwide, but usually few of them are common in certain populations. Here in Sudan and according to the data from the surrounding area four variants (B, A, A- and Mediterranean) are suspected to be more common, which were the ones included in this study.