Effect of Nigella sativa L. (Black Cumin) on Certain Blood Values and Immunoglobulins

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Safia Mohamed Babiker El Hag, El Hag
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An experiment was designed to investigate effect of feeding different doses of seeds of Nigella sativa for considerable long periods in male and female rabbits. The animals were divided into four groups, two of both sex received low doses of N. sativa as 2% of their food and the other two groups received high doses of 10%. Blood samples were taken before application of treatment to record normal values, then every week after treatment for a period of 8 weeks. Serum total proteins, albumin and total globulins, protein: reactions percentage, calcium concentration plus the activity of Aspartate amino-transferase AST (SGOT), Alanine amino-transferase ALT (SGPT). Enzymes were measured from each sample. Some haematological parameters were studied and compared with nominal values which included total white blood cell (WBC) count, its differential count, red blood cell (RBC) count haemoglobin concentration and erythrocyte sedimentation rate (ESR). The results revealed significant changes in the values of total proteins, albumin and total globulins. Calcium concentration and the enzymes were not affected at high or low doses. TWBC, RBC and haemoglobin values showed very significant increase in all the animals whereas ESR decreased from normal of 1.3 mm/hr to zero. Values were not affected by sex of the animals and the dose of the treatment. Death times of rabbits were recorded after infection with Pasteurella multocida and the result showed a significant difference due to both dose and sex. Histopathological changes in various vital organs showed no significant differences between control and treated animals.
Effect of Nigella sativa L. (Black Cumin) on Certain Blood Values and Immunoglobulins