Hyperreactive Malarial Splenomegaly (HMS) in Malaria Endemic Area in Eastern Sudan
Hyperreactive Malarial Splenomegaly (HMS) in Malaria Endemic Area in Eastern Sudan
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Date
2015-03-04
Authors
Allam, Mushal
M. Elhassan, Ibrahim
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Abstract
Hyrerreactive Malarial Splenomegaly (HMS) is a condition affecting
adults in certain malarious areas. The present work was carried out in
Kassala city, Eastern Sudan where HMS is considered as highly
prevalent. The objectives of the study were to describe the epidemiology
and magnitude of the disease in the area, help local clinicians to diagnose,
and differentiate HMS cases from other diseases causing splenomegaly
and to apply modern investigative methods particularly Nested
Polymerase Chain Reaction (PCR) for detection of malaria parasites in
HMS cases.
A cross-sectional study was carried out in four health centers in the city
between January and March 2004. 114 (11.2%) out of 1010 medical cases
were reported had enlarge spleens. Identification using the major
diagnostic criteria supported by clinical and laboratories investigations
was revealed that 87 (8.6%) cases were HMS.
All the cases included in this study are permanent residents of Kassala
city. Forty one percent patients are Beni Amer, 25% Shaikia, 19.5%
Hadendoa and 14% are from other tribes. Sixty three percent of HMS
cases were males and 37% were females. The mean age of 27.7 years
(median= 25 years).
Clinical investigations showed that all cases suffered from abdominal
pain in upper left quadrant and all had palpable firm spleen (10-26 cm)
from the costal margin. Most of cases gave a past history fever associated
with headache. The mean value of body temperature of all studied
patients is in normal range (37ºC).
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Hyperreactive Malarial Splenomegaly (HMS) in Malaria Endemic Area in Eastern Sudan