The Effect of Chronic Renal Failure on Hepatic Functions in Sudanese Patients
The Effect of Chronic Renal Failure on Hepatic Functions in Sudanese Patients
No Thumbnail Available
Date
2015-04-08
Authors
Ibrahim, Bedour
Journal Title
Journal ISSN
Volume Title
Publisher
University of Khartoum
Abstract
There is abundant evidence that animal studies in chronic renal
failure show a major down regulation of hepatic cytochrome P450
metabolism and hepatic functions are reduced; however, direct evidence in
humans is lacking.
This study is carried out in the period from October 2003 to October
2004 and the purpose of it is to outline the effect of chronic renal failure
on human hepatic functions. Liver functions in Sudanese patients with
chronic renal failure were studied. Study subjects were 45 patients (11
females and 34 males) with chronic renal failure under regular
heamodialysis (2 times per week) and 20 healthy persons (control). Blood
samples were collected from the patients (pre-dialysis) and the controls in
order to measure serum albumin, total protein, serum bilirubin levels as
well as aspartate transaminase (AST), alanine transaminase (ALT) and
alkaline phosphatase activities (ALP).
Chronic renal failure patients exhibited a decrease in serum albumin
level (p<0.05) while total protein level and alkaline phosphatase activity
were increased (p<0.05). Chronic renal failure did not alter AST and ALT
activities. Serum bilirubin levels were unaffected.
From this study it is concluded that chronic renal failure has no
clear effect upon the liver functions in humans and that it may be
attributed to the positive effect of dialysis removal of toxins outside the
body.
Description
133 Pages
Keywords
Chronic Renal Failure,Hepatic,Functions, Sudanese Patients;Kidney structure;Chronic renal failure