Hepatoprotective Effects Of Some Medicinal Plants In Rats In Sudan

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Date
2015-04-09
Authors
HASSAN, NUHA
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Publisher
UOFK
Abstract
The hepatoprotective study of Raphanus sativusand Lepidium sativumseeds extracts was performed on rats in which liver damage was induced by carbon tetrachloride (CCL4). The oral administration of the methanolic and water extracts of Raphanus sativus (200 and 400 mg/kg) significantly reduced the CCL4 induced hepatotoxicity as indicatedby inhibition of increased serum AST, ALT and ALP activities and bilirubin concentration. The effect of methanolic and ethanolic extracts of Lepidium sativum (200and 400mg/kg) on liver damaged produced by CCL4was less evident as reflected by measurement of serum AST, ALT and ALP activities and bilirubin concentration and histopathological changes. Toxicity study of both plants revealed that Raphanus sativushad no adverse effect on liver while Lepidium sativumcaused mild vacuolation of hepatocytes. These results indicate that Raphanus sativusis more effective in the protection against CCL4-induced liver damage than Lepidium sativum.
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Keywords
Hepatoprotectiv,Medicinal Plants, Rats,Sudan
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