C-Reactive Protein in Diabetics with and without Peripheral Arterial Disease

Abstract

Background: C-reactive protein is a new emerging predictive marker of ischaemic heart diseases; it has been postulated that the substance has a role in the pathogenesis of peripheral arterial disease (PAD). Methods: This is a cross sectional descriptive study conducted at Khartoum teaching hospital & Jabir Abu Al-iz centre from 5\1\2011 to 5\2\2011. The aim was to measure CRP levels in diabetics with and without PAD and to relate the concentration of CRP to duration of diabetes mellitus and ages of the patients. Study population (n=116) of whom 81 diabetics grouped into 41 diabetics with PAD symptoms and 40 without PAD symptoms, other 35 subjects were normal control. A questionnaire was utilized to collect data, blood samples obtained, separated into sera and using immunometric assay CRP levels were measured at the same time for all patients Results: CRP levels were positively correlated with duration of DM and ages of the peripheral arterial disease diabetics͕ ƌсϬ͘ϲϵϮ Ɖ-ǀĂůƵĞ Ϭ͘ϬϬϬ ĂŶĚ ƌсϬ͘ϱϱϭ Ɖ-ǀĂůƵĞс Ϭ͘ϬϬϮrespectively. PAD had higher CRP levels in comparison to non-PAD diabetics; mean CRP level is ϭϴ͘ϱversus ϭϮ͘Ϭϲ respectively p-ǀĂůƵĞсϬ͘Ϭϯϯ͘ Conclusion: The linear correlation between CRP levels and duration of DM and ages of diabetics is stronger in PAD group of patients. The mean CRP level in PAD group equals one fold and half when compared to that of non PAD group.