Prevalence of beta haemoglobin variants in Sudanese sickle disease patients.

Abstract

Sudan is a multi-racial country with a mixture of Arab-African blood. Sickle cell disease is an important cause of morbidity and mortality among indigenous and immigrant ethnic groups in it. Patients with this disease exhibit a wide spectrum of clinical behavior. The combination of Hb S with other genetic defects of hemoglobin is known to be one of the factors influencing this variation in disease severity. The aim of this study was to detect the presence of some beta haemoglobin variants combining with haemoglobin "S" among Sudanese sickle cell patients.